Tag | Content |
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UniProt Accession | RHOA_HUMAN; P61586; |
Entrez ID | 387 |
GenBank Protein ID | NM_001313941.1; NM_001664.3; |
GenBank Nucleotide ID | NP_001300870.1; NP_001655.1; |
Protein Name | Transforming protein RhoA (Rho cDNA clone 12) (h12) |
Gene Name | RHOA; ARH12; ARHA; RHO12 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPA(view all) |
Sequence (Fasta) | MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT 60 AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 120 LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ 180 ARRGKKKSGC LVL 194 |
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Database | Annotation |
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Cancer Gene Census | diffuse gastric, T cell lymphomas, paediatric Burkitt lymphoma |
CTD (Curated) (count: 12) (view all) | MESH:D000014
; Abnormalities, Drug-Induced MESH:D002277 ; Carcinoma MESH:D004195 ; Disease Models, Animal MESH:D065630 ; Hernias, Diaphragmatic, Congenital MESH:D007119 ; Immunoblastic Lymphadenopathy MESH:D016399 ; Lymphoma, T-Cell |
DisGeNet (Curated) (count: 9) (view all) | C0005695; Bladder Neoplasm
C0020981; Angioimmunoblastic Lymphadenopathy C0027626; Neoplasm Invasiveness C0033687; Proteinuria C0038356; Stomach Neoplasms C0079772; T-Cell Lymphoma |
GWASdb (count: 4) | rs2878298; Crohn's disease; Crohn's disease
rs11716445; Tourette syndrome; Gilles de la Tourette syndrome|obsessive-compulsive disorder|attention deficit hyperactivity disorder rs7621003; Crohn's disease; Crohn's disease rs7648841; Crohn's disease; Crohn's disease |
PTM | Modification Sites |
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Phosphorylation (count: 5) | 156 NRIGAFGYMECSAKT dbPAF
160 AFGYMECSAKTKDGV dbPAF 188 ARRGKKKSGCLVL** dbPAF 34 KDQFPEVYVPTVFEN dbPAF 66 DTAGQEDYDRLRPLS dbPAF |
Acetylation (count: 2) | 135 RRELAKMKQEPVKPE PLMD
162 GYMECSAKTKDGVRE PLMD |
Ubiquitination (count: 7) (view all) | 118 PIILVGNKKDLRNDE PLMD
119 IILVGNKKDLRNDEH PLMD 133 HTRRELAKMKQEPVK PLMD 135 RRELAKMKQEPVKPE PLMD 140 KMKQEPVKPEEGRDM PLMD 162 GYMECSAKTKDGVRE PLMD |
Methylation (count: 1) | 119 IILVGNKKDLRNDEH PLMD |