| Tag | Content |
|---|---|
| UniProt Accession | CXCR4_HUMAN; P61073; |
| Entrez ID | 7852 |
| GenBank Protein ID | NM_001008540.2; NM_001348056.1; NM_001348059.1; NM_001348060.1; NM_003467.2; |
| GenBank Nucleotide ID | NP_001008540.1; NP_001334985.1; NP_001334988.1; NP_001334989.1; NP_003458.1; |
| Protein Name | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived facto |
| Gene Name | CXCR4 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.;(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:9427609, PubMed:10074122, PubMed:10756055). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). |
| Sequence (Fasta) | MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI 60 LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL 120 YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEKVVYVGV WIPALLLTIP DFIFANVSEA 180 DDRYICDRFY PNDLWVVVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT 240 TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI 300 LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS 353 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | WM |
| CTD (Curated) (count: 8) (view all) | MESH:D001171
; Arthritis, Juvenile MESH:D001172 ; Arthritis, Rheumatoid MESH:D001943 ; Breast Neoplasms MESH:D002471 ; Cell Transformation, Neoplastic MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis |
| HGMD (count: 5) | CD031036; WHIM syndrome; Small deletions
CM030831; WHIM syndrome; Missense/nonsense CM045454; WHIM syndrome; Missense/nonsense CM066016; WHIM syndrome; Missense/nonsense CM030832; WHIM syndrome; Missense/nonsense |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 22) (view all) | 12 SIYTSDNYTEEMGSG dbPAF
157 LLAEKVVYVGVWIPA dbPAF 18 NYTEEMGSGDYDSMK dbPAF 312 LGAKFKTSAQHALTS dbPAF 318 TSAQHALTSVSRGSS dbPAF 319 SAQHALTSVSRGSSL dbPAF |
| Ubiquitination (count: 3) | 310 AFLGAKFKTSAQHAL PLMD
327 VSRGSSLKILSKGKR PLMD 331 SSLKILSKGKRGGHS PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |