Tag | Content |
---|---|
UniProt Accession | PPLA_RAT; P61016; |
Entrez ID | 64672 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Cardiac phospholamban (PLB) |
Gene Name | Pln |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). |
Sequence (Fasta) | MEKVQYLTRS AIRRASTIEM PQQARQNLQN LFINFCLILI CLLLICIIVM LL 53 |
|
Database | Annotation |
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CTD (Curated) (count: 6) | MESH:C563690
; Cardiomyopathy, Dilated, 1p OMIM:613874 ; CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 18 MESH:D009203 ; Myocardial Infarction MESH:D015428 ; Myocardial Reperfusion Injury MESH:D017682 ; Myocardial Stunning MESH:D018487 ; Ventricular Dysfunction, Left |
PTM | Modification Sites |
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Phosphorylation (count: 2) | 16 RSAIRRASTIEMPQQ dbPAF
17 SAIRRASTIEMPQQA dbPAF |
Acetylation (count: 1) | 3 *****MEKVQYLTRS PLMD |