| Tag | Content |
|---|---|
| UniProt Accession | PP4C_HUMAN; P60510; |
| Entrez ID | 5531 |
| GenBank Protein ID | NM_001303503.1; NM_001303504.1; NM_001303506.1; NM_001303507.1; NM_002720.2; |
| GenBank Nucleotide ID | NP_001290432.1; NP_001290433.1; NP_001290435.1; NP_001290436.1; NP_002711.1; |
| Protein Name | Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X) |
| Gene Name | PPP4C; PPP4; PPX |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. |
| Sequence (Fasta) | MAEISDLDRQ IEQLRRCELI KESEVKALCA KAREILVEES NVQRVDSPVT VCGDIHGQFY 60 DLKELFRVGG DVPETNYLFM GDFVDRGFYS VETFLLLLAL KVRYPDRITL IRGNHESRQI 120 TQVYGFYDEC LRKYGSVTVW RYCTEIFDYL SLSAIIDGKI FCVHGGLSPS IQTLDQIRTI 180 DRKQEVPHDG PMCDLLWSDP EDTTGWGVSP RGAGYLFGSD VVAQFNAAND IDMICRAHQL 240 VMEGYKWHFN ETVLTVWSAP NYCYRCGNVA AILELDEHLQ KDFIIFEAAP QETRGIPSKK 300 PVADYFL 308 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 1) | rs2278557; Heart rate; heart conduction disease |
| PTM | Modification Sites |
|---|---|
| Acetylation (count: 3) | 21 LRRCELIKESEVKAL PLMD
300 TRGIPSKKPVADYFL PLMD 31 EVKALCAKAREILVE PLMD |
| Ubiquitination (count: 9) (view all) | 133 FYDECLRKYGSVTVW PLMD
183 QIRTIDRKQEVPHDG PLMD 21 LRRCELIKESEVKAL PLMD 26 LIKESEVKALCAKAR PLMD 281 ELDEHLQKDFIIFEA PLMD 299 ETRGIPSKKPVADYF PLMD |
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