P56945

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession BCAR1_HUMAN; P56945;
Entrez ID 9564
GenBank Protein ID NM_001170714.1; NM_001170715.1; NM_001170716.1; NM_001170717.1; NM_001170718.1; NM_001170719.1; NM_001170720.1; NM_014567.3; XM_017023897.1;
GenBank Nucleotide ID NP_001164185.1; NP_001164186.1; NP_001164187.1; NP_001164188.1; NP_001164189.1; NP_001164190.1; NP_001164191.1; NP_055382.2; XP_016879386.1;
Protein Name Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene Name BCAR1; CAS; CASS1; CRKAS
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionDocking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
Sequence
(Fasta)		MNHLNVLAKA LYDNVAESPD ELSFRKGDIM TVLEQDTQGL DGWWLCSLHG RQGIVPGNRL 60
KILVGMYDKK PAGPGPGPPA TPAQPQPGLH APAPPASQYT PMLPNTYQPQ PDSVYLVPTP 120
SKAQQGLYQV PGPSPQFQSP PAKQTSTFSK QTPHHPFPSP ATDLYQVPPG PGGPAQDIYQ 180
VPPSAGMGHD IYQVPPSMDT RSWEGTKPPA KVVVPTRVGQ GYVYEAAQPE QDEYDIPRHL 240
LAPGPQDIYD VPPVRGLLPS QYGQEVYDTP PMAVKGPNGR DPLLEVYDVP PSVEKGLPPS 300
NHHAVYDVPP SVSKDVPDGP LLREETYDVP PAFAKAKPFD PARTPLVLAA PPPDSPPAED 360
VYDVPPPAPD LYDVPPGLRR PGPGTLYDVP RERVLPPEVA DGGVVDSGVY AVPPPAEREA 420
PAEGKRLSAS STGSTRSSQS ASSLEVAGPG REPLELEVAV EALARLQQGV SATVAHLLDL 480
AGSAGATGSW RSPSEPQEPL VQDLQAAVAA VQSAVHELLE FARSAVGNAA HTSDRALHAK 540
LSRQLQKMED VHQTLVAHGQ ALDAGRGGSG ATLEDLDRLV ACSRAVPEDA KQLASFLHGN 600
ASLLFRRTKA TAPGPEGGGT LHPNPTDKTS SIQSRPLPSP PKFTSQDSPD GQYENSEGGW 660
MEDYDYVHLQ GKEEFEKTQK ELLEKGSITR QGKSQLELQQ LKQFERLEQE VSRPIDHDLA 720
NWTPAQPLAP GRTGGLGPSD RQLLLFYLEQ CEANLTTLTN AVDAFFTAVA TNQPPKIFVA 780
HSKFVILSAH KLVFIGDTLS RQAKAADVRS QVTHYSNLLC DLLRGIVATT KAAALQYPSP 840
SAAQDMVERV KELGHSTQQF RRVLGQLAAA 871

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationNeuroblastomaP9442079
[Reference]: Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells
2PhosphorylationMelanomaU7577968; 23872147
[Reference]: An analysis of the tyrosine phosphorylation levels of p130Cas revealed higher levels of phosphorylation in cancer cell lines (MCF7 and A375) than in corresponding normal cell lines (MCF10A and MEL-STV)
3PhosphorylationBreast cancer/tumor/carcinomaU23872147
[Reference]: An analysis of the tyrosine phosphorylation levels of p130Cas revealed higher levels of phosphorylation in cancer cell lines (MCF7 and A375) than in corresponding normal cell lines (MCF10A and MEL-STV)
4Tyrosine PhosphorylationBreast cancer/tumor/carcinomaMCF-7 cell lineUY1221937722
[Reference]: CAS Y12 site is phosphorylated in vivo, and Y12 phosphorylation is elevated in invasive cancer cells
5Tyrosine PhosphorylationColon cancer/carcinomaDLD cell lineUY1221937722
[Reference]: CAS Y12 site is phosphorylated in vivo, and Y12 phosphorylation is elevated in invasive cancer cells
6Tyrosine PhosphorylationColon cancer/carcinomaPY12822710723
[Reference]: We engineered CRC cells homozygous for a p130Cas Y128F knock-in mutant and found that these cells exhibit significantly reduced migration and colony formation, impaired anchorage-independent growth, slower xenograft tumor growth in nude mice and have decreased phosphorylation of AKT.
7Tyrosine PhosphorylationBreast cancer/tumor/carcinomaUY23426867768
[Reference]: A truncated phosphorylated p130Cas substrate domain is sufficient to drive breast cancer growth and metastasis formation in vivo.
8Tyrosine PhosphorylationBreast cancer/tumor/carcinomaUY24926867768
[Reference]: These studies provide strong evidence that the phosphorylated p130Cas SD motifs 6-10 (Y236, Y249, Y267, Y287, and Y306) are important for driving mammary carcinoma progression.
9Tyrosine PhosphorylationBreast cancer/tumor/carcinomaUY26726867768
[Reference]: These studies provide strong evidence that the phosphorylated p130Cas SD motifs 6-10 (Y236, Y249, Y267, Y287, and Y306) are important for driving mammary carcinoma progression.
10Tyrosine PhosphorylationBreast cancer/tumor/carcinomaUY28726867768
[Reference]: These studies provide strong evidence that the phosphorylated p130Cas SD motifs 6-10 (Y236, Y249, Y267, Y287, and Y306) are important for driving mammary carcinoma progression.
11Tyrosine PhosphorylationBreast cancer/tumor/carcinomaUY30626867768
[Reference]: These studies provide strong evidence that the phosphorylated p130Cas SD motifs 6-10 (Y236, Y249, Y267, Y287, and Y306) are important for driving mammary carcinoma progression.
12Tyrosine PhosphorylationGastric cancerPY41023109808
[Reference]: Crosstalk between EGFR and integrin affects invasion and proliferation of gastric cancer cell line, SGC7901
13Tyrosine PhosphorylationOvarian cancer/carcinomacell linePY41023486563
[Reference]: From our results that demonstrate that silencing p130Cas abrogates LPA-induced migration of ovarian cancer cells and that LPAR1/3 as well as Gi2 are involved in the phosphorylation of p130Cas, it can be deduced that LPA-mediated migration of ovarian cancer involves the LPAR1/3-Gi2-p130Cas signaling nexus

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D009361 ; Neoplasm Invasiveness
MESH:D010190 ; Pancreatic Neoplasms
GWASdb
(count: 10)
(view all)		rs16957552; LDL cholesterol; atherosclerosis|coronary artery disease
rs16957552; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs16957552; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs36097424; Alzheimer's disease (late onset); Alzheimer's disease
rs1035540; Amygdala reactivity; disease of mental health
rs1862737; Cognitive performance; cognitive disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 50)
(view all)		 113       TYQPQPDSVYLVPTP     dbPAF
115       QPQPDSVYLVPTPSK     dbPAF
12        NVLAKALYDNVAESP     dbPAF
128       SKAQQGLYQVPGPSP     dbPAF
134       LYQVPGPSPQFQSPP     dbPAF
139       GPSPQFQSPPAKQTS     dbPAF
Acetylation
(count: 2)		 680       EEFEKTQKELLEKGS     PLMD
831       RGIVATTKAAALQYP     PLMD
Ubiquitination
(count: 1)		 702       QLELQQLKQFERLEQ     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
A7KAX9P56945HPRD
B4DLN2P56945HPRD
B7Z2A4P56945HPRD
E7ESA6P56945HPRD; IntAct; MINT
E9PHZ3P56945HPRD
O14495P56945HPRD
O15259P56945HPRD
O15357P56945HPRD; IntAct
O43281P56945HPRD; IntAct
O60231P56945MINT
O75807P56945HPRD; IntAct
P00519P56945HPRD
P00533P56945IntAct
P03372P56945HPRD
P06239P56945HPRD
P06241P56945HPRD; IntAct
P06396P56945HPRD
P07332P56945HPRD
P07948P56945HPRD
P08631P56945HPRD
P10586P56945HPRD
P11021P56945HPRD; IntAct
P12931P56945HPRD; IntAct; MINT
P16333P56945HPRD
P18031P56945HPRD; MINT
P27986P56945HPRD
P31947P56945MINT
P42574P56945HPRD
P46108P56945HPRD; IntAct; MINT
P46109P56945HPRD
P49023P56945HPRD
P50281P56945HPRD; MINT
P56945P60953MINT
P56945P62993HPRD
P56945P63104HPRD
P56945P68366HPRD; IntAct
P56945P98161HPRD
P56945Q04917IntAct
P56945Q05209HPRD; MINT
P56945Q07912MINT
P56945Q13905HPRD
P56945Q14185HPRD
P56945Q14209HPRD; IntAct
P56945Q14289HPRD
P56945Q14511HPRD
P56945Q15654HPRD; IntAct
P56945Q15942IntAct
P56945Q68CZ2IntAct
P56945Q6UVK1HPRD
P56945Q8N5H7HPRD
P56945Q96B97HPRD
P56945Q96IF1HPRD
P56945Q96PU4IntAct
P56945Q9BRG2HPRD
P56945Q9C0H9IntAct;HPRD
P56945Q9H0Q3IntAct
P56945Q9H270HPRD; IntAct
P56945Q9HD43HPRD
P56945Q9Y5K6HPRD