Tag | Content |
---|---|
UniProt Accession | RAG2_HUMAN; P55895; |
Entrez ID | 5897 |
GenBank Protein ID | NM_000536.3; NM_001243785.1; NM_001243786.1; |
GenBank Nucleotide ID | NP_000527.2; NP_001230714.1; NP_001230715.1; |
Protein Name | V(D)J recombination-activating protein 2 (RAG-2) |
Gene Name | RAG2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phos(view all) |
Sequence (Fasta) | MSLQMVTVSN NIALIQPGFS LMNFDGQVFF FGQKGWPKRS CPTGVFHLDV KHNHVKLKPT 60 IFSKDSCYLP PLRYPATCTF KGSLESEKHQ YIIHGGKTPN NEVSDKIYVM SIVCKNNKKV 120 TFRCTEKDLV GDVPEARYGH SINVVYSRGK SMGVLFGGRS YMPSTHRTTE KWNSVADCLP 180 CVFLVDFEFG CATSYILPEL QDGLSFHVSI AKNDTIYILG GHSLANNIRP ANLYRIRVDL 240 PLGSPAVNCT VLPGGISVSS AILTQTNNDE FVIVGGYQLE NQKRMICNII SLEDNKIEIR 300 EMETPDWTPD IKHSKIWFGS NMGNGTVFLG IPGDNKQVVS EGFYFYMLKC AEDDTNEEQT 360 TFTNSQTSTE DPGDSTPFED SEEFCFSAEA NSFDGDDEFD TYNEDDEEDE SETGYWITCC 420 PTCDVDINTW VPFYSTELNK PAMIYCSHGD GHWVHAQCMD LAERTLIHLS AGSNKYYCNE 480 HVEIARALHT PQRVLPLKKP PMKSLRKKGS GKILTPAKKS FLRRLFD 528 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 7) (view all) | MESH:D001169
; Arthritis, Experimental MESH:C567115 ; Combined Cellular And Humoral Immune Defects With Granulomas MESH:D004802 ; Eosinophilia MESH:D008679 ; Metaplasia MESH:D065626 ; Non-alcoholic Fatty Liver Disease MESH:C538564 ; Reticuloendotheliosis, familial, with eosinophilia |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 7) (view all) | 121 CKNNKKVTFRCTEKD dbPAF
138 GDVPEARYGHSINVV dbPAF 146 GHSINVVYSRGKSMG dbPAF 291 RMICNIISLEDNKIE dbPAF 346 VSEGFYFYMLKCAED dbPAF 365 EQTTFTNSQTSTEDP dbPAF |