P55210

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CASP7_HUMAN; P55210;
Entrez ID 840
GenBank Protein ID NM_001227.4; NM_001267056.1; NM_001267057.1; NM_001267058.1; NM_001320911.1; NM_033338.5; NM_033339.4; NM_033340.3;
GenBank Nucleotide ID NP_001218.1; NP_001253985.1; NP_001253986.1; NP_001253987.1; NP_001307840.1; NP_203124.1; NP_203125.1; NP_203126.1;
Protein Name Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene Name CASP7; MCH3
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
Sequence
(Fasta)		MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT TRDRVPTYQY 60
NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC FRSLGFDVIV YNDCSCAKMQ 120
DLLKKASEED HTNAACFACI LLSHGEENVI YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL 180
FFIQACRGTE LDDGIQADSG PINDTDANPR YKIPVEADFL FAYSTVPGYY SWRSPGRGSW 240
FVQALCSILE EHGKDLEIMQ ILTRVNDRVA RHFESQSDDP HFHEKKQIPC VVSMLTKELY 300
FSQ 304

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationBreast cancer/tumor/carcinomacell lineP21555521
[Reference]: Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 5)		MESH:D001943 ; Breast Neoplasms
MESH:D015470 ; Leukemia, Myeloid, Acute
MESH:D008106 ; Liver Cirrhosis, Experimental
MESH:D015428 ; Myocardial Reperfusion Injury
MESH:D014820 ; Vitiligo
GWASdb
(count: 7)
(view all)		rs3124743; Alcohol dependence; alcohol dependence
rs17090911; Multiple complex diseases; Null
rs11196449; Alcohol dependence; alcohol dependence
rs11196449; Progressive supranuclear palsy; progressive supranuclear palsy
rs3814231; Cognitive impairment induced by topiramate; cognitive disorder
rs3814231; Vitiligo; vitiligo

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 14)
(view all)		 157       IYGKDGVTPIKDLTA     dbPAF
16        EEQGVEDSANEDSVD     dbPAF
173       FRGDRCKTLLEKPKL     dbPAF
21        EDSANEDSVDAKPDR     dbPAF
234       PGYYSWRSPGRGSWF     dbPAF
239       WRSPGRGSWFVQALC     dbPAF
Acetylation
(count: 3)		 160       KDGVTPIKDLTAHFR     PLMD
38        FVPSLFSKKKKNVTM     PLMD
80        INNKNFDKVTGMGVR     PLMD
Ubiquitination
(count: 9)
(view all)		 125       KMQDLLKKASEEDHT     PLMD
160       KDGVTPIKDLTAHFR     PLMD
172       HFRGDRCKTLLEKPK     PLMD
286       DPHFHEKKQIPCVVS     PLMD
38        FVPSLFSKKKKNVTM     PLMD
39        VPSLFSKKKKNVTMR     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource