P55087

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession AQP4_HUMAN; P55087;
Entrez ID 361
GenBank Protein ID NM_001650.5; NM_004028.4;
GenBank Nucleotide ID NP_001641.1; NP_004019.1;
Protein Name Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)
Gene Name AQP4
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionForms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
Sequence
(Fasta)		MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL LSLGSTINWG 60
GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV TVAMVCTRKI SIAKSVFYIA 120
AQCLGAIIGA GILYLVTPPS VVGGLGVTMV HGNLTAGHGL LVELIITFQL VFTIFASCDS 180
KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG 240
AVLAGGLYEY VFCPDVEFKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGVVH 300
VIDVDRGEEK KGKDQSGEVL SSV 324

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationAstrocytoma/Astrocytoma glioblastomaNS18019761816
[Reference]: PKC regulation of AQP4 was lost after mutational inactivation of the consensus PKC phosphorylation site S180A.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:D001321 ; Autistic Disorder
MESH:D009471 ; Neuromyelitis Optica
MESH:D013226 ; Status Epilepticus
MESH:D013119 ; Spinal Cord Injuries
DisGeNet (Curated)
(count: 7)
(view all)		C0004352; Autistic Disorder
C0011570; Mental Depression
C0011581; Depressive disorder
C0027873; Neuromyelitis Optica
C0036341; Schizophrenia
C0038220; Status Epilepticus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 7)
(view all)		 180       TIFASCDSKRTDVTG     dbPAF
273       FSKAAQQTKGSYMEV     dbPAF
276       AAQQTKGSYMEVEDN     dbPAF
277       AQQTKGSYMEVEDNR     dbPAF
285       MEVEDNRSQVETDDL     dbPAF
316       EKKGKDQSGEVLSSV     dbPAF
Methylation
(count: 1)		 295       ETDDLILKPGVVHVI     PLMD