| Tag | Content |
|---|---|
| UniProt Accession | EPHB1_HUMAN; P54762; |
| Entrez ID | 2047 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) |
| Gene Name | EPHB1; ELK; EPHT2; HEK6; NET |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilateral(view all) |
| Sequence (Fasta) | MALDYLLLLL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV 60 CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV 120 IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY 180 GACMSLLSVR VFFKKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC 240 NGDGEWMVPI GRCTCKPGYE PENSVACKAC PAGTFKASQE AEGCSHCPSN SRSPAEASPI 300 CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIIC 360 KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT PYTFDIQAIN GVSSKSPFPP 420 QHVSVNITTN QAAPSTVPIM HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEHNEFN 480 SSMARSQTNT ARIDGLRPGM VYVVQVRART VAGYGKFSGK MCFQTLTDDD YKSELREQLP 540 LIAGSAAAGV VFVVSLVAIS IVCSRKRAYS KEAVYSDKLQ HYSTGRGSPG MKIYIDPFTY 600 EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI KTLKAGYSEK 660 QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMIITEFM ENGALDSFLR QNDGQFTVIQ 720 LVGMLRGIAA GMKYLAEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS 780 SLGGKIPVRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD 840 YRLPPPMDCP AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT VATITAVPSQ 900 PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED LLRIGITLAG 960 HQKKILNSIH SMRVQISQSP TAMA 985 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 40) (view all) | rs11712035; Urinary metabolites; kidney disease
rs6439522; Urinary metabolites; kidney disease rs6439524; Urinary metabolites; kidney disease rs12489463; Temperament (bipolar disorder); bipolar disorder rs13072597; Temperament (bipolar disorder); bipolar disorder rs13073658; Response to alcohol consumption (flushing response); alcohol abuse|alcohol dependence |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 24) (view all) | 164 KVNTEVRSFGPLTRN dbPAF
264 PGYEPENSVACKACP dbPAF 395 ECRVSISSLWAHTPY dbPAF 5 ***MALDYLLLLLLA dbPAF 575 AYSKEAVYSDKLQHY dbPAF 582 YSDKLQHYSTGRGSP dbPAF |
| Glycation (count: 2) | 124 TDSVIATKKSAFWSE PLMD
136 WSEAPYLKVDTIAAD PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |