Tag | Content |
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UniProt Accession | AAPK2_HUMAN; P54646; |
Entrez ID | 5563 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) |
Gene Name | PRKAA2; AMPK; AMPK2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of (view all) |
Sequence (Fasta) | MAEKQKHDGR VKIGHYVLGD TLGVGTFGKV KIGEHQLTGH KVAVKILNRQ KIRSLDVVGK 60 IKREIQNLKL FRHPHIIKLY QVISTPTDFF MVMEYVSGGE LFDYICKHGR VEEMEARRLF 120 QQILSAVDYC HRHMVVHRDL KPENVLLDAH MNAKIADFGL SNMMSDGEFL RTSCGSPNYA 180 APEVISGRLY AGPEVDIWSC GVILYALLCG TLPFDDEHVP TLFKKIRGGV FYIPEYLNRS 240 VATLLMHMLQ VDPLKRATIK DIREHEWFKQ DLPSYLFPED PSYDANVIDD EAVKEVCEKF 300 ECTESEVMNS LYSGDPQDQL AVAYHLIIDN RRIMNQASEF YLASSPPSGS FMDDSAMHIP 360 PGLKPHPERM PPLIADSPKA RCPLDALNTT KPKSLAVKKA KWHLGIRSQS KPYDIMAEVY 420 RAMKQLDFEW KVVNAYHLRV RRKNPVTGNY VKMSLQLYLV DNRSYLLDFK SIDDEVVEQR 480 SGSSTPQRSC SAAGLHRPRS SFDSTTAESH SLSGSLTGSL TGSTLSSVSP RLGSHTMDFF 540 EMCASLITTL AR 553 |
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Database | Annotation |
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CTD (Curated) (count: 5) | MESH:D006332
; Cardiomegaly MESH:D009202 ; Cardiomyopathies MESH:D018149 ; Glucose Intolerance MESH:D007333 ; Insulin Resistance MESH:D020521 ; Stroke |
HGMD (count: 5) | CS066310; LDL-cholesterol & total cholesterol levels, assoc.; Splicing
CS066311; LDL-cholesterol & total cholesterol levels, assoc.; Splicing CS066309; LDL-cholesterol & total cholesterol levels, assoc.; Splicing CS066312; LDL-cholesterol & total cholesterol levels, assoc.; Splicing CS066313; LDL-cholesterol & total cholesterol levels, assoc.; Splicing |
GWASdb (count: 5) | rs2746349; Urinary metabolites; kidney disease
rs2746347; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease rs2179761; Urinary metabolites; kidney disease rs1342382; Asthma; asthma rs1342382; Urinary metabolites; kidney disease |
PTM | Modification Sites |
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Phosphorylation (count: 22) (view all) | 161 KIADFGLSNMMSDGE dbPAF
165 FGLSNMMSDGEFLRT dbPAF 172 SDGEFLRTSCGSPNY dbPAF 173 DGEFLRTSCGSPNYA dbPAF 176 FLRTSCGSPNYAAPE dbPAF 179 TSCGSPNYAAPEVIS dbPAF |
Acetylation (count: 1) | 69 KREIQNLKLFRHPHI PLMD |
Ubiquitination (count: 8) (view all) | 141 MVVHRDLKPENVLLD PLMD
154 LDAHMNAKIADFGLS PLMD 379 PLIADSPKARCPLDA PLMD 401 SLAVKKAKWHLGIRS PLMD 411 LGIRSQSKPYDIMAE PLMD 45 TGHKVAVKILNRQKI PLMD |
Sumoylation (count: 1) | 401 SLAVKKAKWHLGIRS PLMD |
Malonylation (count: 1) | 69 KREIQNLKLFRHPHI PLMD |
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