Tag | Content |
---|---|
UniProt Accession | MK12_HUMAN; P53778; |
Entrez ID | 6300 |
GenBank Protein ID | NM_001303252.2; NM_002969.5; |
GenBank Nucleotide ID | NP_001290181.1; NP_002960.2; |
Protein Name | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) |
Gene Name | MAPK12; ERK6; SAPK3 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are dow(view all) |
Sequence (Fasta) | MSSPPPARSG FYRQEVTKTA WEVRAVYRDL QPVGSGAYGA VCSAVDGRTG AKVAIKKLYR 60 PFQSELFAKR AYRELRLLKH MRHENVIGLL DVFTPDETLD DFTDFYLVMP FMGTDLGKLM 120 KHEKLGEDRI QFLVYQMLKG LRYIHAAGII HRDLKPGNLA VNEDCELKIL DFGLARQADS 180 EMTGYVVTRW YRAPEVILNW MRYTQTVDIW SVGCIMAEMI TGKTLFKGSD HLDQLKEIMK 240 VTGTPPAEFV QRLQSDEAKN YMKGLPELEK KDFASILTNA SPLAVNLLEK MLVLDAEQRV 300 TAGEALAHPY FESLHDTEDE PQVQKYDDSF DDVDRTLDEW KRVTYKEVLS FKPPRQLGAR 360 VSKETPL 368 |
|
PTM | Modification Sites |
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Phosphorylation (count: 6) | 180 GLARQADSEMTGYVV dbPAF
183 RQADSEMTGYVVTRW dbPAF 185 ADSEMTGYVVTRWYR dbPAF 188 EMTGYVVTRWYRAPE dbPAF 27 AWEVRAVYRDLQPVG dbPAF 3 *****MSSPPPARSG dbPAF |
Network | Interaction | ||
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A | B | Source | |