Tag | Content |
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UniProt Accession | CEBPA_MOUSE; P53566; |
Entrez ID | 12606 |
GenBank Protein ID | NM_001287514.1; NM_001287515.1; NM_001287521.1; NM_007678.3; |
GenBank Nucleotide ID | NP_001274443.1; NP_001274444.1; NP_001274450.1; NP_031704.2; |
Protein Name | CCAAT/enhancer-binding protein alpha (C/EBP alpha) |
Gene Name | Cebpa; Cebp |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta (PubMed:8415748, PubMed:15107404, PubMed:15589173). Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB (PubMed:15509779). Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP) (Pub(view all) |
Sequence (Fasta) | MESADFYEVE PRPPMSSHLQ SPPHAPSNAA FGFPRGAGPA PPPAPPAAPE PLGGICEHET 60 SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAAGPAGG GGDFDYPGAP AGPGGAVMSA 120 GAHGPPPGYG CAAAGYLDGR LEPLYERVGA PALRPLVIKQ EPREEDEAKQ LALAGLFPYQ 180 PPPPPPPPHP HASPAHLAAP HLQFQIAHCG QTTMHLQPGH PTPPPTPVPS PHAAPALGAA 240 GLPGPGSALK GLAGAHPDLR TGGGGGGSGA GAGKAKKSVD KNSNEYRVRR ERNNIAVRKS 300 RDKAKQRNVE TQQKVLELTS DNDRLRKRVE QLSRELDTLR GIFRQLPESS LVKAMGNCA 360 |
|
Database | Annotation |
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CTD (Curated) (count: 12) (view all) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D002294 ; Carcinoma, Squamous Cell MESH:D004646 ; Emphysema MESH:D006258 ; Head and Neck Neoplasms MESH:D007247 ; Infertility, Female MESH:D015470 ; Leukemia, Myeloid, Acute |
PTM | Modification Sites |
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Phosphorylation (count: 5) | 193 PPPHPHASPAHLAAP dbPAF
21 PMSSHLQSPPHAPSN dbPAF 222 HLQPGHPTPPPTPVP dbPAF 226 GHPTPPPTPVPSPHA dbPAF 230 PPPTPVPSPHAAPAL dbPAF |
Sumoylation (count: 1) | 159 ALRPLVIKQEPREED PLMD |