P53396

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	ACLY_HUMAN; P53396;
Entrez ID	47
GenBank Protein ID	NM_001096.2; NM_001303274.1; NM_001303275.1; NM_198830.1; XM_005257395.1;
GenBank Nucleotide ID	NP_001087.2; NP_001290203.1; NP_001290204.1; NP_942127.1; XP_005257452.1;
Protein Name	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)
Gene Name	ACLY
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Functional Description ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Sequence (Fasta)	MSAKAISEQT GKELLYKFIC TTSAIQNRFK YARVTPDTDW ARLLQDHPWL LSQNLVVKPD 60 QLIKRRGKLG LVGVNLTLDG VKSWLKPRLG QEATVGKATG FLKNFLIEPF VPHSQAEEFY 120 VCIYATREGD YVLFHHEGGV DVGDVDAKAQ KLLVGVDEKL NPEDIKKHLL VHAPEDKKEI 180 LASFISGLFN FYEDLYFTYL EINPLVVTKD GVYVLDLAAK VDATADYICK VKWGDIEFPP 240 PFGREAYPEE AYIADLDAKS GASLKLTLLN PKGRIWTMVA GGGASVVYSD TICDLGGVNE 300 LANYGEYSGA PSEQQTYDYA KTILSLMTRE KHPDGKILII GGSIANFTNV AATFKGIVRA 360 IRDYQGPLKE HEVTIFVRRG GPNYQEGLRV MGEVGKTTGI PIHVFGTETH MTAIVGMALG 420 HRPIPNQPPT AAHTANFLLN ASGSTSTPAP SRTASFSESR ADEVAPAKKA KPAMPQDSVP 480 SPRSLQGKST TLFSRHTKAI VWGMQTRAVQ GMLDFDYVCS RDEPSVAAMV YPFTGDHKQK 540 FYWGHKEILI PVFKNMADAM RKHPEVDVLI NFASLRSAYD STMETMNYAQ IRTIAIIAEG 600 IPEALTRKLI KKADQKGVTI IGPATVGGIK PGCFKIGNTG GMLDNILASK LYRPGSVAYV 660 SRSGGMSNEL NNIISRTTDG VYEGVAIGGD RYPGSTFMDH VLRYQDTPGV KMIVVLGEIG 720 GTEEYKICRG IKEGRLTKPI VCWCIGTCAT MFSSEVQFGH AGACANQASE TAVAKNQALK 780 EAGVFVPRSF DELGEIIQSV YEDLVANGVI VPAQEVPPPT VPMDYSWARE LGLIRKPASF 840 MTSICDERGQ ELIYAGMPIT EVFKEEMGIG GVLGLLWFQK RLPKYSCQFI EMCLMVTADH 900 GPAVSGAHNT IICARAGKDL VSSLTSGLLT IGDRFGGALD AAAKMFSKAF DSGIIPMEFV 960 NKMKKEGKLI MGIGHRVKSI NNPDMRVQIL KDYVRQHFPA TPLLDYALEV EKITTSKKPN 1020 LILNVDGLIG VAFVDMLRNC GSFTREEADE YIDIGALNGI FVLGRSMGFI GHYLDQKRLK 1080 QGLYRHPWDD ISYVLPEHMS M 1102 Fasta Sequence >P53396\|ACLY\|Homo sapiens (Human) MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Acetylation	Lung cancer/carcinoma	A549 cell line	P	K540	23932781
1	[Reference]: Acetylation of ACLY Promotes Cell Proliferation and De Novo Lipid Synthesis
2	Acetylation	Lung cancer/carcinoma	A549 cell line	P	K546	23932781
2	[Reference]: Acetylation of ACLY Promotes Cell Proliferation and De Novo Lipid Synthesis

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:D006528 ; Carcinoma, Hepatocellular MESH:D006333 ; Heart Failure MESH:D009765 ; Obesity
GWASdb (count: 1)	rs8071234; Lymphocyte counts; asthma\|leukemia\|lymphoma\|lymphopenia\|cardiovascular system disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 52) (view all)	1073 SMGFIGHYLDQKRLK dbPAF 1084 KRLKQGLYRHPWDDI dbPAF 1093 HPWDDISYVLPEHMS dbPAF 1100 YVLPEHMSM****** dbPAF 131 YATREGDYVLFHHEG dbPAF 227 KVDATADYICKVKWG dbPAF 23 YKFICTTSAIQNRFK dbPAF 247 PPFGREAYPEEAYIA dbPAF 260 IADLDAKSGASLKLT dbPAF 317 APSEQQTYDYAKTIL dbPAF 325 DYAKTILSLMTREKH dbPAF 328 KTILSLMTREKHPDG dbPAF 364 IVRAIRDYQGPLKEH dbPAF 384 VRRGGPNYQEGLRVM dbPAF 442 ANFLLNASGSTSTPA dbPAF 444 FLLNASGSTSTPAPS dbPAF 445 LLNASGSTSTPAPSR dbPAF 446 LNASGSTSTPAPSRT dbPAF 447 NASGSTSTPAPSRTA dbPAF 451 STSTPAPSRTASFSE dbPAF 453 STPAPSRTASFSESR dbPAF 455 PAPSRTASFSESRAD dbPAF 457 PSRTASFSESRADEV dbPAF 459 RTASFSESRADEVAP dbPAF 478 KPAMPQDSVPSPRSL dbPAF 481 MPQDSVPSPRSLQGK dbPAF 484 DSVPSPRSLQGKSTT dbPAF 531 PSVAAMVYPFTGDHK dbPAF 574 DVLINFASLRSAYDS dbPAF 581 SLRSAYDSTMETMNY dbPAF 588 STMETMNYAQIRTIA dbPAF 593 MNYAQIRTIAIIAEG dbPAF 606 EGIPEALTRKLIKKA dbPAF 619 KADQKGVTIIGPATV dbPAF 639 GCFKIGNTGGMLDNI dbPAF 649 MLDNILASKLYRPGS dbPAF 652 NILASKLYRPGSVAY dbPAF 663 SVAYVSRSGGMSNEL dbPAF 667 VSRSGGMSNELNNII dbPAF 675 NELNNIISRTTDGVY dbPAF 677 LNNIISRTTDGVYEG dbPAF 678 NNIISRTTDGVYEGV dbPAF 682 SRTTDGVYEGVAIGG dbPAF 695 GGDRYPGSTFMDHVL dbPAF 696 GDRYPGSTFMDHVLR dbPAF 839 GLIRKPASFMTSICD dbPAF 842 RKPASFMTSICDERG dbPAF 843 KPASFMTSICDERGQ dbPAF 922 RAGKDLVSSLTSGLL dbPAF 930 SLTSGLLTIGDRFGG dbPAF 952 MFSKAFDSGIIPMEF dbPAF 979 GIGHRVKSINNPDMR dbPAF
Acetylation (count: 29) (view all)	1077 IGHYLDQKRLKQGLY PLMD 12 AISEQTGKELLYKFI PLMD 148 DVGDVDAKAQKLLVG PLMD 151 DVDAKAQKLLVGVDE PLMD 159 LLVGVDEKLNPEDIK PLMD 17 TGKELLYKFICTTSA PLMD 230 ATADYICKVKWGDIE PLMD 259 YIADLDAKSGASLKL PLMD 265 AKSGASLKLTLLNPK PLMD 369 RDYQGPLKEHEVTIF PLMD 4 ****MSAKAISEQTG PLMD 468 ADEVAPAKKAKPAMP PLMD 538 YPFTGDHKQKFYWGH PLMD 540 FTGDHKQKFYWGHKE PLMD 546 QKFYWGHKEILIPVF PLMD 554 EILIPVFKNMADAMR PLMD 58 LSQNLVVKPDQLIKR PLMD 616 LIKKADQKGVTIIGP PLMD 630 PATVGGIKPGCFKIG PLMD 64 VKPDQLIKRRGKLGL PLMD 68 QLIKRRGKLGLVGVN PLMD 86 DGVKSWLKPRLGQEA PLMD 944 GALDAAAKMFSKAFD PLMD 948 AAAKMFSKAFDSGII PLMD 962 IPMEFVNKMKKEGKL PLMD 968 NKMKKEGKLIMGIGH PLMD 97 GQEATVGKATGFLKN PLMD 978 MGIGHRVKSINNPDM PLMD 991 DMRVQILKDYVRQHF PLMD
Ubiquitination (count: 48) (view all)	1077 IGHYLDQKRLKQGLY PLMD 1080 YLDQKRLKQGLYRHP PLMD 12 AISEQTGKELLYKFI PLMD 148 DVGDVDAKAQKLLVG PLMD 151 DVDAKAQKLLVGVDE PLMD 159 LLVGVDEKLNPEDIK PLMD 166 KLNPEDIKKHLLVHA PLMD 167 LNPEDIKKHLLVHAP PLMD 17 TGKELLYKFICTTSA PLMD 220 YVLDLAAKVDATADY PLMD 230 ATADYICKVKWGDIE PLMD 232 ADYICKVKWGDIEFP PLMD 259 YIADLDAKSGASLKL PLMD 265 AKSGASLKLTLLNPK PLMD 272 KLTLLNPKGRIWTMV PLMD 369 RDYQGPLKEHEVTIF PLMD 4 ****MSAKAISEQTG PLMD 468 ADEVAPAKKAKPAMP PLMD 469 DEVAPAKKAKPAMPQ PLMD 471 VAPAKKAKPAMPQDS PLMD 488 SPRSLQGKSTTLFSR PLMD 498 TLFSRHTKAIVWGMQ PLMD 538 YPFTGDHKQKFYWGH PLMD 540 FTGDHKQKFYWGHKE PLMD 546 QKFYWGHKEILIPVF PLMD 554 EILIPVFKNMADAMR PLMD 562 NMADAMRKHPEVDVL PLMD 58 LSQNLVVKPDQLIKR PLMD 616 LIKKADQKGVTIIGP PLMD 630 PATVGGIKPGCFKIG PLMD 635 GIKPGCFKIGNTGGM PLMD 64 VKPDQLIKRRGKLGL PLMD 650 LDNILASKLYRPGSV PLMD 68 QLIKRRGKLGLVGVN PLMD 732 YKICRGIKEGRLTKP PLMD 780 VAKNQALKEAGVFVP PLMD 82 NLTLDGVKSWLKPRL PLMD 836 RELGLIRKPASFMTS PLMD 86 DGVKSWLKPRLGQEA PLMD 918 IICARAGKDLVSSLT PLMD 944 GALDAAAKMFSKAFD PLMD 948 AAAKMFSKAFDSGII PLMD 962 IPMEFVNKMKKEGKL PLMD 964 MEFVNKMKKEGKLIM PLMD 968 NKMKKEGKLIMGIGH PLMD 97 GQEATVGKATGFLKN PLMD 978 MGIGHRVKSINNPDM PLMD 991 DMRVQILKDYVRQHF PLMD
Glycation (count: 1)	177 LVHAPEDKKEILASF PLMD
Malonylation (count: 14) (view all)	1077 IGHYLDQKRLKQGLY PLMD 1080 YLDQKRLKQGLYRHP PLMD 151 DVDAKAQKLLVGVDE PLMD 230 ATADYICKVKWGDIE PLMD 369 RDYQGPLKEHEVTIF PLMD 471 VAPAKKAKPAMPQDS PLMD 488 SPRSLQGKSTTLFSR PLMD 538 YPFTGDHKQKFYWGH PLMD 630 PATVGGIKPGCFKIG PLMD 68 QLIKRRGKLGLVGVN PLMD 836 RELGLIRKPASFMTS PLMD 968 NKMKKEGKLIMGIGH PLMD 97 GQEATVGKATGFLKN PLMD 978 MGIGHRVKSINNPDM PLMD
Methylation (count: 2)	964 MEFVNKMKKEGKLIM PLMD 965 EFVNKMKKEGKLIMG PLMD
Succinylation (count: 1)	12 AISEQTGKELLYKFI PLMD