Tag | Content |
---|---|
UniProt Accession | VAV2_HUMAN; P52735; |
Entrez ID | 7410 |
GenBank Protein ID | NM_001134398.1; NM_003371.3; XM_005272213.1; |
GenBank Nucleotide ID | NP_001127870.1; NP_003362.2; XP_005272270.1; |
Protein Name | Guanine nucleotide exchange factor VAV2 (VAV-2) |
Gene Name | VAV2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). |
Sequence (Fasta) | MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60 NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 120 AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV 180 QQPMIRYMQK MGMTEDDKRN CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV 240 FINLEDLIKV HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL 300 LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK 360 EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH 420 TKQDRYLFLF DKVVIVCKRK GYSYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY 480 LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC 540 KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN 600 PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR 660 PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI 720 KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR 780 SPASCASYNF SFLSPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG 840 DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ 879 |
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Database | Annotation |
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GWASdb (count: 19) (view all) | rs642193; Myopia (severe); myopia
rs622035; Parkinson's disease; Parkinson's disease rs669443; Adiposity; obesity rs602990; Information processing speed; cognitive disorder rs2073888; Normoxic and mild-hypoxic adaptation in populations residing at low and moderate altitudes; asthma|chronic obstructive pulmonary disease rs10993803; Normoxic and mild-hypoxic adaptation in populations residing at low and moderate altitudes; asthma|chronic obstructive pulmonary disease |
PTM | Modification Sites |
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Phosphorylation (count: 19) (view all) | 116 ISAVSRLSLHSIAQN dbPAF
119 VSRLSLHSIAQNKGI dbPAF 142 TENDDDVYRSLEELA dbPAF 159 HDLGEDIYDCVPCED dbPAF 172 EDGGDDIYEDIIKVE dbPAF 213 IQETEAKYYRTLEDI dbPAF |