P52735

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession VAV2_HUMAN; P52735;
Entrez ID 7410
GenBank Protein ID NM_001134398.1; NM_003371.3; XM_005272213.1;
GenBank Nucleotide ID NP_001127870.1; NP_003362.2; XP_005272270.1;
Protein Name Guanine nucleotide exchange factor VAV2 (VAV-2)
Gene Name VAV2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionGuanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Sequence
(Fasta)
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 120
AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV 180
QQPMIRYMQK MGMTEDDKRN CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV 240
FINLEDLIKV HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL 300
LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK 360
EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH 420
TKQDRYLFLF DKVVIVCKRK GYSYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY 480
LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC 540
KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN 600
PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR 660
PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI 720
KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR 780
SPASCASYNF SFLSPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG 840
DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ 879

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationNon-small cell lung cancer/carcinomaDY17223699534
[Reference]: Fer KD NSCLC cells showed reduced Vav2 tyrosine phosphorylation that was correlated with direct Fer-mediated phosphorylation of Vav2 on tyrosine-172, which was previously reported to increase the guanine nucleotide exchange factor activity of Vav2. Indeed, Fer KD cells displayed defects in Rac-GTP localization to lamellipodia, cell migration, and cell invasion in vitro

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 19)
(view all)
rs642193; Myopia (severe); myopia
rs622035; Parkinson's disease; Parkinson's disease
rs669443; Adiposity; obesity
rs602990; Information processing speed; cognitive disorder
rs2073888; Normoxic and mild-hypoxic adaptation in populations residing at low and moderate altitudes; asthma|chronic obstructive pulmonary disease
rs10993803; Normoxic and mild-hypoxic adaptation in populations residing at low and moderate altitudes; asthma|chronic obstructive pulmonary disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 19)
(view all)
116       ISAVSRLSLHSIAQN     dbPAF
119       VSRLSLHSIAQNKGI     dbPAF
142       TENDDDVYRSLEELA     dbPAF
159       HDLGEDIYDCVPCED     dbPAF
172       EDGGDDIYEDIIKVE     dbPAF
213       IQETEAKYYRTLEDI     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource
O14513P52735IntAct
O15524P52735HPRD
O43432P52735IntAct
O75575P52735IntAct
O75674P52735IntAct
O75688P52735IntAct
O95155P52735IntAct
P00533P52735HPRD
P02686P52735MINT
P04066P52735IntAct
P04626P52735MINT
P15391P52735HPRD
P16070P52735HPRD
P16471P52735HPRD; IntAct
P21860P52735MINT
P22674P52735IntAct
P22681P52735HPRD
P29323P52735HPRD
P43405P52735HPRD; MINT
P49354P52735IntAct
P49368P52735IntAct
P50502P52735IntAct
P51956P52735HPRD; IntAct
P52597P52735IntAct
P52735P52735HPRD
P52735P54725IntAct
P52735P61586HPRD
P52735P62993HPRD; IntAct
P52735P63000HPRD
P52735P78314HPRD; MINT
P52735P78362IntAct
P52735P78371IntAct
P52735P84022IntAct
P52735P84095HPRD
P52735Q12874IntAct
P52735Q13503IntAct
P52735Q13573IntAct
P52735Q14C86IntAct
P52735Q15633IntAct
P52735Q58F21IntAct
P52735Q5F1R6IntAct
P52735Q5SW79IntAct
P52735Q7L1Q6IntAct
P52735Q7Z3K3IntAct
P52735Q7Z6E9IntAct
P52735Q8IZP0MINT
P52735Q8NB14IntAct
P52735Q8NC51IntAct
P52735Q8ND90IntAct
P52735Q8NFC6IntAct
P52735Q8TEX9IntAct
P52735Q8WUB8IntAct
P52735Q8WWU5IntAct
P52735Q8WZ42IntAct
P52735Q92564IntAct
P52735Q92598IntAct
P52735Q96JH7IntAct
P52735Q9BXP5IntAct
P52735Q9H992IntAct
P52735Q9NR09IntAct
P52735Q9NV56IntAct
P52735Q9Y3E7IntAct
P52735Q9Y4X5IntAct
P52735Q9Y6E0IntAct