| Tag | Content |
|---|---|
| UniProt Accession | STA5B_HUMAN; P51692; |
| Entrez ID | 6777 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Signal transducer and activator of transcription 5B |
| Gene Name | STAT5B |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. |
| Sequence (Fasta) | MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN PQENIKATQL 60 LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV 120 REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL 180 RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 240 RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 300 QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 360 NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS 420 LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA 480 TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN 540 SSSHLEDYSG LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 600 QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL 660 GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV KPQIKQVVPE FVNASADAGG 720 GSATYMDQAP SPAVCPQAHY NMYPQNPDSV LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ 780 WIPHAQS 788 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | large granular lymphocytic leukaemia, skin basal cell, APL |
| CTD (Curated) (count: 5) | MESH:C537871
; Laron syndrome type 2 MESH:D054066 ; Leukemia, Large Granular Lymphocytic MESH:D016399 ; Lymphoma, T-Cell MESH:D016410 ; Lymphoma, T-Cell, Cutaneous MESH:C536783 ; T-Lymphocytopenia |
| HGMD (count: 5) | CD072495; Growth hormone insensitivity; Small deletions
CI064735; Growth hormone insensitivity; Small insertions CI057048; Growth hormone insensitivity; Small insertions CM065474; Growth hormone insensitivity; Missense/nonsense CM032382; Growth hormone insensitivity; Missense/nonsense |
| GWASdb (count: 2) | rs17500235; Coronary heart disease; coronary artery disease
rs6503691; Post-operative nausea and vomiting; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 25) (view all) | 114 RCIRHILYNEQRLVR dbPAF
127 VREANNGSSPAGSLA dbPAF 128 REANNGSSPAGSLAD dbPAF 132 NGSSPAGSLADAMSQ dbPAF 193 FGPLAQLSPQERLSR dbPAF 372 NPPQVKATIISEQQA dbPAF |
| Ubiquitination (count: 2) | 140 LADAMSQKHLQINQT PLMD
694 PCESATAKAVDGYVK PLMD |
| Sumoylation (count: 3) | 384 QQAKSLLKNENTRND PLMD
516 EALNMKFKAEVQSNR PLMD 701 KAVDGYVKPQIKQVV PLMD |
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