P51667

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	MLRV_MOUSE; P51667;
Entrez ID	17906
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v)
Gene Name	Myl2; Mylpc
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:22426213, PubMed:16908724, PubMed:10409661). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794). Functional Description Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:22426213, PubMed:16908724, PubMed:10409661). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794).
Sequence (Fasta)	MAPKKAKKRI EGGSSNVFSM FEQTQIQEFK EAFTIMDQNR DGFIDKNDLR DTFAALGRVN 60 VKNEEIDEMI KEAPGPINFT VFLTMFGEKL KGADPEETIL NAFKVFDPEG KGSLKADYVR 120 EMLTTQAERF SKEEIDQMFA AFPPDVTGNL DYKNLVHIIT HGEEKD 167 Fasta Sequence >P51667\|Myl2; Mylpc\|Mus musculus (Mouse) MAPKKAKKRIEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Dilated cardiomyopathy		P	S14/15	22426213
1	[Reference]: Loss of Mlc2v Ser14/Ser15 phosphorylation in vivo predisposes mice to dilated cardiomyopathy, heart failure, and premature death
2	Serine Phosphorylation	Heart failure		P	S14/15	22426213
2	[Reference]: Loss of Mlc2v Ser14/Ser15 phosphorylation in vivo predisposes mice to dilated cardiomyopathy, heart failure, and premature death

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:C563865 ; Cardiomyopathy, Familial Hypertrophic, 10 MESH:D002312 ; Cardiomyopathy, Hypertrophic MESH:D024741 ; Cardiomyopathy, Hypertrophic, Familial

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 8) (view all)	113 FDPEGKGSLKADYVR dbPAF 118 KGSLKADYVREMLTT dbPAF 125 YVREMLTTQAERFSK dbPAF 14 KKRIEGGSSNVFSMF dbPAF 15 KRIEGGSSNVFSMFE dbPAF 19 GGSSNVFSMFEQTQI dbPAF 24 VFSMFEQTQIQEFKE dbPAF 34 QEFKEAFTIMDQNRD dbPAF
Ubiquitination (count: 8) (view all)	111 KVFDPEGKGSLKADY PLMD 115 PEGKGSLKADYVREM PLMD 132 TQAERFSKEEIDQMF PLMD 165 IITHGEEKD****** PLMD 46 NRDGFIDKNDLRDTF PLMD 62 ALGRVNVKNEEIDEM PLMD 8 MAPKKAKKRIEGGSS PLMD 91 TMFGEKLKGADPEET PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

P01326	P51667	BioGRID
P14869	P51667	BioGRID
P16054	P51667	IntAct
P51667	Q80ZI6	MINT