Tag | Content |
---|---|
UniProt Accession | IRAK1_HUMAN; P51617; |
Entrez ID | 3654 |
GenBank Protein ID | NM_001025242.1; NM_001025243.1; NM_001569.3; |
GenBank Nucleotide ID | NP_001020413.1; NP_001020414.1; NP_001560.2; |
Protein Name | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) |
Gene Name | IRAK1; IRAK |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin(view all) |
Sequence (Fasta) | MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 60 RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPLPS PGTTAPRPSS 120 IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS QTHSGPELGL VPSPASLWPP PPSPAPSSTK 180 PGPESSVSLL QGARPFPFCW PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR 240 LKENADLEWT AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL 300 HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLTPKLGDFG 360 LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVVLETLAG 420 QRAVKTHGAR TKYLKDLVEE EAEEAGVALR STQSTLQAGL AADAWAAPIA MQIYKKHLDP 480 RPGPCPPELG LGLGQLACCC LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP 540 SPQENSYVSS TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR 600 SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS ASSSSEPPQI 660 IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD RQGPEESDEF QS 713 |
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Database | Annotation |
---|---|
CTD (Curated) (count: 3) | MESH:D001172
; Arthritis, Rheumatoid MESH:D003324 ; Coronary Artery Disease MESH:D020925 ; Hypoxia-Ischemia, Brain |
DisGeNet (Curated) (count: 3) | C0003873; Rheumatoid Arthritis
C0752308; Hypoxia-Ischemia, Brain C1956346; Coronary Artery Disease |
GWASdb (count: 1) | rs3027898; Alzheimer's disease; Alzheimer's disease |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 19) (view all) | 100 LRARDIITAWHPPAP dbPAF
131 PAEAEAWSPRKLPSS dbPAF 144 SSASTFLSPAFPGSQ dbPAF 173 SLWPPPPSPAPSSTK dbPAF 209 LCEISRGTHNFSEEL dbPAF 371 FSRFAGSSPSQSSMV dbPAF |
Acetylation (count: 1) | 217 HNFSEELKIGEGGFG PLMD |
Ubiquitination (count: 7) (view all) | 217 HNFSEELKIGEGGFG PLMD
239 RNTVYAVKRLKENAD PLMD 242 VYAVKRLKENADLEW PLMD 342 SLIHGDIKSSNVLLD PLMD 355 LDERLTPKLGDFGLA PLMD 397 YLPEEYIKTGRLAVD PLMD |
Malonylation (count: 1) | 397 YLPEEYIKTGRLAVD PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |