| Tag | Content |
|---|---|
| UniProt Accession | GRAM_HUMAN; P51124; |
| Entrez ID | 3004 |
| GenBank Protein ID | NM_001258351.1; NM_005317.3; |
| GenBank Nucleotide ID | NP_001245280.1; NP_005308.1; |
| Protein Name | Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease) |
| Gene Name | GZMM; MET1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. |
| Sequence (Fasta) | MEACVSSLLV LALGALSVGS SFGTQIIGGR EVIPHSRPYM ASLQRNGSHL CGGVLVHPKW 60 VLTAAHCLAQ RMAQLRLVLG LHTLDSPGLT FHIKAAIQHP RYKPVPALEN DLALLQLDGK 120 VKPSRTIRPL ALPSKRQVVA AGTRCSMAGW GLTHQGGRLS RVLRELDLQV LDTRMCNNSR 180 FWNGSLSPSM VCLAADSKDQ APCKGDSGGP LVCGKGRVLA RVLSFSSRVC TDIFKPPVAT 240 AVAPYVSWIR KVTGRSA 258 |
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| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 5) | 134 IRPLALPSKRQVVAA dbPAF
187 RFWNGSLSPSMVCLA dbPAF 224 RVLARVLSFSSRVCT dbPAF 226 LARVLSFSSRVCTDI dbPAF 83 RLVLGLHTLDSPGLT dbPAF |