P51111

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	HD_RAT; P51111;
Entrez ID	29424
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Huntingtin (Huntington disease protein homolog) (HD protein homolog)
Gene Name	Htt; Hd; Hdh
Organism	Rattus norvegicus
NCBI Taxa ID	10116
Functional Description	May play a role in microtubule-mediated transport or vesicle function. Functional Description May play a role in microtubule-mediated transport or vesicle function.
Sequence (Fasta)	MKAFESLKSF QQQQQQQQPP PQPPPPPPPP PQPPQPPPQG QPPPPPPLPG PAEEPLHRPK 60 KELSATKKDR VNHCLTICEN IVAQSLRNSP EFQKLLGIAM ELFLLCSDDA SRRRMVADEC 120 LNKVIKALMD SNLPRLQLEL YKEIKKNGAP RSLRAALWRF AELAHLVRPQ KCRPYLVNLL 180 PCLTRTSKRP EESVQETLAA AVPKIMASFG NFANDNEIKV LLKAFIANLK SSSPTVRRTA 240 AGSAVSICQH SRRTQYFYNW LLNVLLGLLV PMEEDHPTLL ILGVLLTLRC LVPLLQQQVK 300 DTSLKGSFGV TRKEMEVSPS AEQLVQVYEL TLHHTQHQDH NVVTGALELL QQLFRTPPPE 360 LLQALTTPGG LGQLTLVREE AGGRGRSGSI VELLAGGGSS CSPVLSRKQK GKVLLGEEEA 420 LEDDSESRSD VSSSAFAASV KSEIGGELAA SSSGVSTPGS VGHDIITEQP RSQHTLQADS 480 VDLSGCDLTS AATDGDEEDI LSHSSSQFSA VPSDPAMDLN DGTQASSPIS DSSQTTTEGP 540 DSAVTPSDSS EIVLDGADSQ YLGVQIGQPQ EEDREAAGVL SGEVSDVFRN SSLALQQAHL 600 LERMGHSRQP SDSSVDKFVS KDEVAEAGDP ESKPCRIKGD IGQPNDDDSA PLVHCVRLLS 660 ASFLLTGEKK ALVPDRDVRV SVKALALSCI GAAVALHPES FFSKLYKVPL STMESTEEQY 720 VSDILNYIDH GDPQVRGATA ILCGTLVYSI LSRSRLRVGD WLGTIRALTG NTFSLVDCIP 780 LLQKTLKDES SVTCKLACTA VRHCVLSLCS SSYSDLGLQL LIDMLPLKNS SYWLVRTELL 840 ETLAEIDFRL VSFLEAKAES LHRGPHHYTG FLKLQERVLN NVVIYLLGDE DPRVRHVAAT 900 TLTRLVPKLF YKCDQGQADP VEAVARDQSS VYLKLLMHET QPPSHFSVST ITRIYRGYSL 960 LPSVTDVTME NNLSRVVAAV SHELITSTTR ALTFGCCEAL CVLSAAFPVC TWSLGWHCGV 1020 PPLSASDESR KSCTVGMASM ILTLLSSAWF PLDLSAIQDA LILAGNLLAA SAPKSLRSSW 1080 ASEEEGSSAA TRQEEIWPAL GDRTLVPMVE QLFSHLLKVI NICAHVLDDE TPGPAIKAAL 1140 PSLTNPPSLS PIRRKGKEKE PGEQTSTPMS PKKGGEASTA SRQSDTSGPV TASKSSSLGS 1200 FYHLPSYLRL HDVLKATHAN YKVTLDLQNS TEKFGGFLRS ALDVLSQILE LATLQDIGKC 1260 VEEVLGYLKS CFSREPMMAT VCVQQLLKTL FGTNLASQFD GLSSNPSKSQ CRAQRLGSSS 1320 VRPGLYHYCF MAPYTHFTQA LADASLRNMV QADQEHDASG WFDVLQKVSA QLKTNLTSVT 1380 KNRADKNAIH NHIRLFEPLV IKALKQYTTT TSVQLQKQVL DLLAQLVQLR VNYCLLDSDQ 1440 VFIGFVLKQF EYIEVGQFRE SEAIIPNIFF FLVLLSYERY HSKQIIGIPK IIQLCDGIMA 1500 SGRKAVTHAI PALQPIVHDL FVLRGTNKAD AGKELETQKE VVVSMLLRLI QYHQVLEMFI 1560 LVLQQCHKEN EDKWKRLSRQ VADIILPMLA KQQMHIDSHE ALGVLNTLFE ILAPSSLRPV 1620 DMLLRSMFIT PSTMASVSTV QLWISGILAI LRVLISQSTE DIVLSRIQEL SFSPYLISCP 1680 VINRLRDGDS NPTLGERSRG KQVKNLPEDT FSRFLLQLVG ILLEDIVTKQ LKVDMSEQQH 1740 TFYCQELGTL LMCLIHIFKS GMFRRITAAA TRLFTSDGCE GSFYTLDSLN ARVRAMVPTH 1800 PALVLLWCQI LLLINHTDHR WWAEVQQTPK RHSLSCTKSL NPQISAEEDS GSAAQLGMCN 1860 REIVRRGALI LFCDYVCQNL HDSEHLTWLI VNHIQDLISL SHEPPVQDFI SAIHRNSAAS 1920 GLFIQAIQSR CENLSTPTTL KKTLQCLEGI HLSQSGAVLT LYVDRLLGTP FRALARMVDT 1980 LACRRVEMLL AANLQSSMAQ LPEEELNRIQ EHLQNTGLAQ RHQRLYSLLD RFRLSTVQDS 2040 LSPLPPVTSH PLDGDGHTSL ETVNPDKDWY LQLVRSQCWT RSDSALLEGA ELVNRIPAED 2100 MSDFMMSSEF NLSLFAPCLS LGMSEIAGSQ KSPLFEAARR VTLDRVTNVV QQLPAVHQVF 2160 QPFLPTEPTA YWSKLNDLFG DTTSYQSLTT LARALAQYLV VLSKVPAPLH LPPEKEGHTV 2220 KFVVMTLEAL SWHLIHEQIP LSLDLQAGLD CCCLALQVPG LWGVLSSPEY VTHTCSLIHC 2280 VRFILEAIAV QPGDQLLGPE SRSHTPRAVR KEEVDSDIQN LSHITSACEM VADMVESLQS 2340 VLALGHKRNS TLPSFLTAVL KNIVVSLARL PLVNSYTRVP PLVWKLGWSP KPGGDFGTVF 2400 PEIPVEFLQE KEVLKEFIYR INTLGWTSRT QFEETWATLL GVLVTQPLVM EQEESPPEED 2460 TERTQIHVLA VQAITSLVLS AMAVPVAGNP AVSCLEQQPR NKPLKALDTR FGRKLSMIRG 2520 IVEQEIQEMV SQRENTATHH SHQAWDPVPS LLPATTGALI SHDKLLLQIN SEREPGNMSY 2580 KLGQVSIHSV WLGNNITPLR EEEWDEEEEE EADAPAPTSP PVSPVNSRKH RAGVDIHSCS 2640 QFLLELYSRW ILPSSAARRT PVILISEVVR SLLVVSDLFT DVPQFEMMYL TLTELRRVHP 2700 SEDEILIQYL VPATCKAAAV LGMDKTVAEP VSRLLESTLR STHLPSQIGA LHGILYVLEC 2760 DLLDDTVKQL IPVVSDYLLS NLKGIAHCVN IHSQQHVLVM CATAFYLMEN YPLDVGPEFS 2820 ASVIQMCGVM LSGSEESTPS VIYHCALRGL ERLLLSEQLS RLDTESLVKL SVDRVNVQSP 2880 HRAMAALGLM LTCMYTGKEK ASPGRASDPS PATPDSESVI VAMERVSVLF DRIRKGFPCE 2940 ARVVARILPQ FLDDFFPPQD VMNKVIGEFL SNQQPYPQFM ATVVYKVFQT LHSAGQSSMV 3000 RDWVMLSLSN FTQRTPVAMA MWSLSCFLVS ASTSPWVSAI LPHVISRMGK LEQVDVNLFC 3060 LVATDFYRHQ IEEEFDRRAF QSVFEVVAAP GSPYHRLLAC LQNVHKVTAC 3111 Fasta Sequence >P51111\|Htt; Hd; Hdh\|Rattus norvegicus (Rat) MKAFESLKSFQQQQQQQQPPPQPPPPPPPPPQPPQPPPQGQPPPPPPLPGPAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAMELFLLCSDDASRRRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTVRRTAAGSAVSICQHSRRTQYFYNWLLNVLLGLLVPMEEDHPTLLILGVLLTLRCLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQALTTPGGLGQLTLVREEAGGRGRSGSIVELLAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSAFAASVKSEIGGELAASSSGVSTPGSVGHDIITEQPRSQHTLQADSVDLSGCDLTSAATDGDEEDILSHSSSQFSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGADSQYLGVQIGQPQEEDREAAGVLSGEVSDVFRNSSLALQQAHLLERMGHSRQPSDSSVDKFVSKDEVAEAGDPESKPCRIKGDIGQPNDDDSAPLVHCVRLLSASFLLTGEKKALVPDRDVRVSVKALALSCIGAAVALHPESFFSKLYKVPLSTMESTEEQYVSDILNYIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLGTIRALTGNTFSLVDCIPLLQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLLIDMLPLKNSSYWLVRTELLETLAEIDFRLVSFLEAKAESLHRGPHHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATTLTRLVPKLFYKCDQGQADPVEAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYSLLPSVTDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCVLSAAFPVCTWSLGWHCGVPPLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAIQDALILAGNLLAASAPKSLRSSWASEEEGSSAATRQEEIWPALGDRTLVPMVEQLFSHLLKVINICAHVLDDETPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQTSTPMSPKKGGEASTASRQSDTSGPVTASKSSSLGSFYHLPSYLRLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQCRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQADQEHDASGWFDVLQKVSAQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQVADIILPMLAKQQMHIDSHEALGVLNTLFEILAPSSLRPVDMLLRSMFITPSTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSFSPYLISCPVINRLRDGDSNPTLGERSRGKQVKNLPEDTFSRFLLQLVGILLEDIVTKQLKVDMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAATRLFTSDGCEGSFYTLDSLNARVRAMVPTHPALVLLWCQILLLINHTDHRWWAEVQQTPKRHSLSCTKSLNPQISAEEDSGSAAQLGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLIVNHIQDLISLSHEPPVQDFISAIHRNSAASGLFIQAIQSRCENLSTPTTLKKTLQCLEGIHLSQSGAVLTLYVDRLLGTPFRALARMVDTLACRRVEMLLAANLQSSMAQLPEEELNRIQEHLQNTGLAQRHQRLYSLLDRFRLSTVQDSLSPLPPVTSHPLDGDGHTSLETVNPDKDWYLQLVRSQCWTRSDSALLEGAELVNRIPAEDMSDFMMSSEFNLSLFAPCLSLGMSEIAGSQKSPLFEAARRVTLDRVTNVVQQLPAVHQVFQPFLPTEPTAYWSKLNDLFGDTTSYQSLTTLARALAQYLVVLSKVPAPLHLPPEKEGHTVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQVPGLWGVLSSPEYVTHTCSLIHCVRFILEAIAVQPGDQLLGPESRSHTPRAVRKEEVDSDIQNLSHITSACEMVADMVESLQSVLALGHKRNSTLPSFLTAVLKNIVVSLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGTVFPEIPVEFLQEKEVLKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEESPPEEDTERTQIHVLAVQAITSLVLSAMAVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSMIRGIVEQEIQEMVSQRENTATHHSHQAWDPVPSLLPATTGALISHDKLLLQINSEREPGNMSYKLGQVSIHSVWLGNNITPLREEEWDEEEEEEADAPAPTSPPVSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSAARRTPVILISEVVRSLLVVSDLFTDVPQFEMMYLTLTELRRVHPSEDEILIQYLVPATCKAAAVLGMDKTVAEPVSRLLESTLRSTHLPSQIGALHGILYVLECDLLDDTVKQLIPVVSDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLMENYPLDVGPEFSASVIQMCGVMLSGSEESTPSVIYHCALRGLERLLLSEQLSRLDTESLVKLSVDRVNVQSPHRAMAALGLMLTCMYTGKEKASPGRASDPSPATPDSESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDVMNKVIGEFLSNQQPYPQFMATVVYKVFQTLHSAGQSSMVRDWVMLSLSNFTQRTPVAMAMWSLSCFLVSASTSPWVSAILPHVISRMGKLEQVDVNLFCLVATDFYRHQIEEEFDRRAFQSVFEVVAAPGSPYHRLLACLQNVHKVTAC

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Huntington's disease		P	S1181	23678106
1	[Reference]: We report here that absence of phosphorylation of HTT at S1181/1201 reduces anxiety/depression-like behaviors and increases hippocampal neurogenesis in mouse

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 4)	MESH:D002105 ; Cadmium Poisoning MESH:D006816 ; Huntington Disease MESH:D020149 ; Manganese Poisoning MESH:D009069 ; Movement Disorders

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 7) (view all)	1150 LTNPPSLSPIRRKGK dbPAF 1170 EQTSTPMSPKKGGEA dbPAF 387 EAGGRGRSGSIVELL dbPAF 389 GGRGRSGSIVELLAG dbPAF 399 ELLAGGGSSCSPVLS dbPAF 402 AGGGSSCSPVLSRKQ dbPAF 611 MGHSRQPSDSSVDKF dbPAF
Acetylation (count: 1)	145 LELYKEIKKNGAPRS PLMD