| Tag | Content |
|---|---|
| UniProt Accession | VASP_HUMAN; P50552; |
| Entrez ID | 7408 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Vasodilator-stimulated phosphoprotein (VASP) |
| Gene Name | VASP |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. |
| Sequence (Fasta) | MSETVICSSR ATVMLYDDGN KRWLPAGTGP QAFSRVQIYH NPTANSFRVV GRKMQPDQQV 60 VINCAIVRGV KYNQATPNFH QWRDARQVWG LNFGSKEDAA QFAAGMASAL EALEGGGPPP 120 PPALPTWSVP NGPSPEEVEQ QKRQQPGPSE HIERRVSNAG GPPAPPAGGP PPPPGPPPPP 180 GPPPPPGLPP SGVPAAAHGA GGGPPPAPPL PAAQGPGGGG AGAPGLAAAI AGAKLRKVSK 240 QEEASGGPTA PKAESGRSGG GGLMEEMNAM LARRRKATQV GEKTPKDESA NQEEPEARVP 300 AQSESVRRPW EKNSTTLPRM KSSSSVTTSE TQPCTPSSSD YSDLQRVKQE LLEEVKKELQ 360 KVKEEIIEAF VQELRKRGSP 381 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D008106 ; Liver Cirrhosis, Experimental |
| GWASdb (count: 3) | rs2301283; Coronary artery calcification; coronary artery disease
rs2301284; Response to taxane treatment (placlitaxel); lung cancer rs4802260; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 29) (view all) | 157 EHIERRVSNAGGPPA dbPAF
16 SRATVMLYDDGNKRW dbPAF 2 ******MSETVICSS dbPAF 239 GAKLRKVSKQEEASG dbPAF 249 EEASGGPTAPKAESG dbPAF 255 PTAPKAESGRSGGGG dbPAF |
| Acetylation (count: 8) (view all) | 21 MLYDDGNKRWLPAGT PLMD
240 AKLRKVSKQEEASGG PLMD 276 AMLARRRKATQVGEK PLMD 283 KATQVGEKTPKDESA PLMD 348 YSDLQRVKQELLEEV PLMD 356 QELLEEVKKELQKVK PLMD |
| Ubiquitination (count: 7) (view all) | 21 MLYDDGNKRWLPAGT PLMD
240 AKLRKVSKQEEASGG PLMD 283 KATQVGEKTPKDESA PLMD 321 STTLPRMKSSSSVTT PLMD 363 KKELQKVKEEIIEAF PLMD 53 SFRVVGRKMQPDQQV PLMD |
| Sumoylation (count: 1) | 286 QVGEKTPKDESANQE PLMD |
| Glycation (count: 2) | 240 AKLRKVSKQEEASGG PLMD
252 SGGPTAPKAESGRSG PLMD |
| Malonylation (count: 1) | 71 CAIVRGVKYNQATPN PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |