P50281

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession MMP14_HUMAN; P50281;
Entrez ID 4323
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene Name MMP14
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionEndopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).
Sequence
(Fasta)
MSPAPRPPRC LLLPLLTLGT ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL RTHTQRSPQS 60
LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG AEIKANVRRK RYAIQGLKWQ 120
HNEITFCIQN YTPKVGEYAT YEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIF 180
FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE 240
LGHALGLEHS SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGGESGFP TKMPPQPRTT 300
SRPSVPDKPK NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF 360
WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF 420
WMPNGKTYFF RGNKYYRFNE ELRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG 480
NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGGGAVSAA 540
AVVLPVLLLL LVLAVGLAVF FFRRHGTPRR LLYCQRSLLD KV 583

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationCervical cancer/carcinomaHela cell linePT56722002060
[Reference]: Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration
2Tyrosine PhosphorylationFibrosarcomaPY57318621744
[Reference]: In this study, we show that in addition to its matrix-degrading activity, phosphorylation of MT1-MMP on its unique tyrosine residue located within its cytoplasmic sequence (Tyr573) may also participate to these processes.?
3MonoubiquitinationBreast cancer/tumor/carcinomaMCF-7 cell linePK58122315223
[Reference]: Membrane type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at Lys581 increases cellular invasion through type I collagen

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 8)
(view all)
MESH:D000230 ; Adenocarcinoma
MESH:D017544 ; Aortic Aneurysm, Abdominal
MESH:D001943 ; Breast Neoplasms
MESH:D002471 ; Cell Transformation, Neoplastic
MESH:D004938 ; Esophageal Neoplasms
MESH:D009361 ; Neoplasm Invasiveness
DisGeNet (Curated)
(count: 21)
(view all)
C0001418; Adenocarcinoma
C0007621; Neoplastic Cell Transformation
C0010038; Corneal Opacity
C0014859; Esophageal Neoplasms
C0017566; Gingival Hyperplasia
C0017567; Gingival Hypertrophy
GWASdb
(count: 5)
rs762052; Response to taxane treatment (placlitaxel); lung cancer
rs17243048; Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin); neutropenia
rs17884841; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs17884841; LDL cholesterol; atherosclerosis|coronary artery disease
rs2236304; Malignant pleural mesothelioma; malignant mesothelioma

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 8)
(view all)
138       YTPKVGEYATYEAIR     dbPAF
140       PKVGEYATYEAIRKA     dbPAF
141       KVGEYATYEAIRKAF     dbPAF
462       VWEGIPESPRGSFMG     dbPAF
567       FFFRRHGTPRRLLYC     dbPAF
573       GTPRRLLYCQRSLLD     dbPAF
Glycation
(count: 1)
173       YIREGHEKQADIMIF     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource