Tag | Content |
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UniProt Accession | MMP14_HUMAN; P50281; |
Entrez ID | 4323 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) |
Gene Name | MMP14 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). |
Sequence (Fasta) | MSPAPRPPRC LLLPLLTLGT ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL RTHTQRSPQS 60 LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG AEIKANVRRK RYAIQGLKWQ 120 HNEITFCIQN YTPKVGEYAT YEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIF 180 FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE 240 LGHALGLEHS SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGGESGFP TKMPPQPRTT 300 SRPSVPDKPK NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF 360 WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF 420 WMPNGKTYFF RGNKYYRFNE ELRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG 480 NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGGGAVSAA 540 AVVLPVLLLL LVLAVGLAVF FFRRHGTPRR LLYCQRSLLD KV 583 |
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Database | Annotation |
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CTD (Curated) (count: 8) (view all) | MESH:D000230
; Adenocarcinoma MESH:D017544 ; Aortic Aneurysm, Abdominal MESH:D001943 ; Breast Neoplasms MESH:D002471 ; Cell Transformation, Neoplastic MESH:D004938 ; Esophageal Neoplasms MESH:D009361 ; Neoplasm Invasiveness |
DisGeNet (Curated) (count: 21) (view all) | C0001418; Adenocarcinoma
C0007621; Neoplastic Cell Transformation C0010038; Corneal Opacity C0014859; Esophageal Neoplasms C0017566; Gingival Hyperplasia C0017567; Gingival Hypertrophy |
GWASdb (count: 5) | rs762052; Response to taxane treatment (placlitaxel); lung cancer
rs17243048; Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin); neutropenia rs17884841; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs17884841; LDL cholesterol; atherosclerosis|coronary artery disease rs2236304; Malignant pleural mesothelioma; malignant mesothelioma |
PTM | Modification Sites |
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Phosphorylation (count: 8) (view all) | 138 YTPKVGEYATYEAIR dbPAF
140 PKVGEYATYEAIRKA dbPAF 141 KVGEYATYEAIRKAF dbPAF 462 VWEGIPESPRGSFMG dbPAF 567 FFFRRHGTPRRLLYC dbPAF 573 GTPRRLLYCQRSLLD dbPAF |
Glycation (count: 1) | 173 YIREGHEKQADIMIF PLMD |
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