Num | PTM | Disease | Cell Type | Type | PTM Site | PMID |
---|
1 | Phosphorylation | Oral squamous cell carcinoma | | D | | 23723304 |
[Reference]: Survival curves show that the survival of patients with high Id-1, p-Akt, p-GSK3? and p-HSF1 expression was significantly worse than those with low Id-1, p-Akt, p-GSK3? and p-HSF1 expression (p=0.000) |
|
2 | Phosphorylation | Small cell lung cancer/carcinoma | | D | | 17972518 |
[Reference]: The P-GSK3beta-ser9 expression was highest in adenocarcinoma (AD) and lowest in small cell carcinomas (SCC), compared with other types of lung carcinoma (p<0.05) |
|
3 | Phosphorylation | Adenocarcinoma | | U | | 17972518 |
[Reference]: The P-GSK3beta-ser9 expression was highest in adenocarcinoma (AD) and lowest in small cell carcinomas (SCC), compared with other types of lung carcinoma (p<0.05) |
|
4 | Phosphorylation | Hepatocellular carcinoma/Hepatocarcinoma/Hepatoma | tumor tissue | U | | 23432902 |
[Reference]: The phosphorylation of GSK3? was up-regulated in cirrhotic patients with hepatocellular carcinoma (HCC) vs. patients without tumour (P < 0.05) |
|
5 | Serine Phosphorylation | Diabetes mellitus | | D | S9 | 15033922 |
[Reference]: Most interestingly, we found that decreased pS21-GSK-3alpha and pS9-GSK-3beta phosphorylation, which is an index of GSK activation, positively correlated with the generation of brain C-terminal fragment (CTF)-gamma cleavage product of amyloid precursor protein, an index of gamma-secretase activity, in the brain of insulin-resistant relative to normoglycemic Tg2576 mice.? |
|
6 | Serine Phosphorylation | Pancreatic cancer/carcinoma/adenocarcinoma | tumor tissue | D | S9 | 23408967 |
[Reference]: Pancreatic cancer cells showed higher basal levels of GSK3? and the Y216-phosphorylated active form (p-GSK3?Y216) and lower levels of the S9-phosphorylated inactive form (p-GSK3?S9) compared to HEK 293 cells |
|
7 | Serine Phosphorylation | Liver cancer | cell line | P | S9 | 23325562 |
[Reference]: Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 mediate ursolic acid induced apoptosis in HepG2 liver cancer cells |
|
8 | Serine Phosphorylation | Lung cancer/carcinoma | cell line | P | S9 | 23149922; 23514933 |
[Reference]: Blocking IL17A reduces the expression of BCL2 and promotes the interaction of BCL2 and GSK3B in BLM-induced fibrotic lung tissue |
|
9 | Serine Phosphorylation | Ovarian cancer/carcinoma | cell line | P | S9 | 23667667 |
[Reference]: Huaier queous extract inhibits ovarian cancer cell motility via the AKT/GSK3?/-catenin pathway |
|
10 | Serine Phosphorylation | Gastric cancer | tumor tissue | P | S9 | 23123500 |
[Reference]: PI3K/Akt-dependent phosphorylation of GSK3? and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration |
|
11 | Serine Phosphorylation | Major depressive disorder | | U | S9 | 22622071 |
[Reference]: Depressed patients had significantly higher levels of pGSK3B as compared to controls (p < 0.001). |
|
12 | Serine Phosphorylation | Squamous cell carcinoma | | U | S9 | 18606491 |
[Reference]: In a mouse epidermal multistage carcinogenesis model, a dramatic increase in pGSK3(Ser9) (inactive form of GSK3?) is observed in late papillomas and squamous cell carcinomas, while a significant decrease in pGSK3(Tyr216) (active form of GSK3b) is detected in squamous cell carcinoma samples compared to normal tissues; this indicates an inactivation of GSK3? occurs during mouse skin carcinogenesis |
|
13 | Serine Phosphorylation | Papillomas | | U | S9 | 18606491 |
[Reference]: In a mouse epidermal multistage carcinogenesis model, a dramatic increase in pGSK3(Ser9) (inactive form of GSK3?) is observed in late papillomas and squamous cell carcinomas, while a significant decrease in pGSK3(Tyr216) (active form of GSK3?) is detected in squamous cell carcinoma samples compared to normal tissues; this indicates an inactivation of GSK3? occurs during mouse skin carcinogenesis |
|
14 | Serine Phosphorylation | Skin cancer | | U | S9 | 18606491 |
[Reference]: In a mouse epidermal multistage carcinogenesis model, a dramatic increase in pGSK3(Ser9) (inactive form of GSK3?) is observed in late papillomas and squamous cell carcinomas, while a significant decrease in pGSK3(Tyr216) (active form of GSK3?) is detected in squamous cell carcinoma samples compared to normal tissues; this indicates an inactivation of GSK3? occurs during mouse skin carcinogenesis |
|
15 | Serine Phosphorylation | Breast cancer/tumor/carcinoma | | U | S9 | 17495324; 27494834 |
[Reference]: Inactivation of GSK3? as measured by its phosphorylation at Ser9 is positively correlated with higher level of H3K27 trimethylation in tumor tissues from breast cancer patients.? |
|
16 | Serine Phosphorylation | Systemic lupus erythematosus | | U | S9 | 23735868 |
[Reference]: Pretreatment with NaHS decreased PHA-induced expression of CDK2, phosphorylation levels of AKT (ser473) and GSK3? (ser9) and increased the expression of p27(Kip1) and p21(WAF1/CIP1) |
|
17 | Serine Phosphorylation | Bipolar disorder | | U | S9 | 16806104 |
[Reference]: The level of phospho-Ser9-GSK3beta in PBMCs was regulated by agents that modified kinases and phosphatases acting on GSK3beta and was increased by in vitro lithium treatment.? |
|
18 | Serine Phosphorylation | Lymphoma | | U | S9 | 20224723 |
[Reference]: We recently reported that mantle cell lymphoma (MCL) frequently shows evidence of GSK-3beta inactivation, since GSK-3beta is phoshorylated at its functionally critical serine 9 residue in all MCL cell lines and the majority of MCL tumors examined. |
|
19 | Tyrosine Phosphorylation | Squamous cell carcinoma | | D | Y216 | 18606491 |
[Reference]: In a mouse epidermal multistage carcinogenesis model, a dramatic increase in pGSK3(Ser9) (inactive form of GSK3?) is observed in late papillomas and squamous cell carcinomas, while a significant decrease in pGSK3(Tyr216) (active form of GSK3) is detected in squamous cell carcinoma samples compared to normal tissues; this indicates an inactivation of GSK3 occurs during mouse skin carcinogenesis |
|
20 | Tyrosine Phosphorylation | Breast cancer/tumor/carcinoma | cell line | P | Y216 | 23565238 |
[Reference]: CG0009 enhanced the inactivating phosphorylation of GSK3? at Ser21 and GSK3? at Ser9 and simultaneously decreased activating phosphorylation of GSK3? at Tyr216, and induced caspase-dependent apoptosis independently of estrogen receptor (ER) expression status |
|
21 | Tyrosine Phosphorylation | Neuroblastoma | | U | Y216 | 24349301 |
[Reference]: Increased in NB10 cells (MYCN amplified neuroblastoma line) compared to NPC cells (normal neural crest line) |
|
22 | Tyrosine Phosphorylation | Pancreatic cancer/carcinoma/adenocarcinoma | tumor tissue | U | Y216 | 23408967 |
[Reference]: Pancreatic cancer cells showed higher basal levels of GSK3 and the Y216-phosphorylated active form (p-GSK3?Y216) and lower levels of the S9-phosphorylated inactive form (p-GSK3S9) compared to HEK 293 cells |
|