| Tag | Content |
|---|---|
| UniProt Accession | NUMB_HUMAN; P49757; |
| Entrez ID | 8650 |
| GenBank Protein ID | NM_001005743.1; NM_001005744.1; NM_001005745.1; NM_001320114.1; NM_003744.5; |
| GenBank Nucleotide ID | NP_001005743.1; NP_001005744.1; NP_001005745.1; NP_001307043.1; NP_003735.3; |
| Protein Name | Protein numb homolog (h-Numb) (Protein S171) |
| Gene Name | NUMB; C14orf41 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. |
| Sequence (Fasta) | MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED 60 AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD 120 RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA 180 TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS 240 SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE 300 LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ 360 SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS 420 SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS 480 PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG 540 TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA 600 DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L 652 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 16) (view all) | rs8013402; Cognitive impairment induced by topiramate; cognitive disorder
rs17126584; Response to taxane treatment (placlitaxel); lung cancer rs10483853; Coronary artery calcification; coronary artery disease rs2333194; Bipolar disorder (mood-incongruent); bipolar disorder rs17781962; Coronary Artery Disease; coronary artery disease rs10141031; Response to methylphenidate treatment; attention deficit hyperactivity disorder|hypertension |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 42) (view all) | 102 LRVVDEKTKDLIVDQ dbPAF
15 FRRKKDVYVPEASRP dbPAF 187 ATFDASRTTFTREGS dbPAF 190 DASRTTFTREGSFRV dbPAF 194 TTFTREGSFRVTTAT dbPAF 20 DVYVPEASRPHQWQT dbPAF |
| Ubiquitination (count: 5) | 174 ERKQKREKECGVTAT PLMD
286 GFPALSQKMSPFKRQ PLMD 626 QWAALENKSKQRTNP PLMD 63 HICEDAVKRLKAERK PLMD 73 KAERKFFKGFFGKTG PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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