Tag | Content |
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UniProt Accession | CEBPA_HUMAN; P49715; |
Entrez ID | 1050 |
GenBank Protein ID | NM_001285829.1; NM_001287424.1; NM_001287435.1; NM_004364.4; |
GenBank Nucleotide ID | NP_001272758.1; NP_001274353.1; NP_001274364.1; NP_004355.2; |
Protein Name | CCAAT/enhancer-binding protein alpha (C/EBP alpha) |
Gene Name | CEBPA; CEBP |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and t(view all) |
Sequence (Fasta) | MESADFYEAE PRPPMSSHLQ SPPHAPSSAA FGFPRGAGPA QPPAPPAAPE PLGGICEHET 60 SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAVGPTGG GGGGDFDYPG APAGPGGAVM 120 PGGAHGPPPG YGCAAAGYLD GRLEPLYERV GAPALRPLVI KQEPREEDEA KQLALAGLFP 180 YQPPPPPPPS HPHPHPPPAH LAAPHLQFQI AHCGQTTMHL QPGHPTPPPT PVPSPHPAPA 240 LGAAGLPGPG SALKGLGAAH PDLRASGGSG AGKAKKSVDK NSNEYRVRRE RNNIAVRKSR 300 DKAKQRNVET QQKVLELTSD NDRLRKRVEQ LSRELDTLRG IFRQLPESSL VKAMGNCA 359 |
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Database | Annotation |
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Cancer Gene Census | AML, MDS |
CTD (Curated) (count: 12) (view all) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D002294 ; Carcinoma, Squamous Cell MESH:D004646 ; Emphysema MESH:D006258 ; Head and Neck Neoplasms MESH:D007247 ; Infertility, Female MESH:D015470 ; Leukemia, Myeloid, Acute |
DisGeNet (Curated) (count: 9) (view all) | C0007137; Squamous cell carcinoma
C0018671; Head and Neck Neoplasms C0021361; Female infertility C0023467; Leukemia, Myelocytic, Acute C0023487; Acute Promyelocytic Leukemia C0027666; Neoplasms, Radiation-Induced |
HGMD (count: 3) | CD043401; Acute myeloid leukaemia; Small deletions
CI087025; Acute myeloid leukaemia; Small insertions CI056483; Acute myeloid leukaemia; Small insertions |
PTM | Modification Sites |
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Phosphorylation (count: 7) (view all) | 190 PPPPPPPSHPHPHPP dbPAF
21 PMSSHLQSPPHAPSS dbPAF 226 HLQPGHPTPPPTPVP dbPAF 230 GHPTPPPTPVPSPHP dbPAF 234 PPPTPVPSPHPAPAL dbPAF 266 AHPDLRASGGSGAGK dbPAF |
Acetylation (count: 1) | 161 ALRPLVIKQEPREED PLMD |
Ubiquitination (count: 3) | 161 ALRPLVIKQEPREED PLMD
313 RNVETQQKVLELTSD PLMD 92 SRQQEKAKAAVGPTG PLMD |
Sumoylation (count: 1) | 161 ALRPLVIKQEPREED PLMD |
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