Tag | Content |
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UniProt Accession | MK08_RAT; P49185; |
Entrez ID | 116554 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (SAPK gamma) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (p54 gamma) |
Gene Name | Mapk8; Jnk1; Prkm8 |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such(view all) |
Sequence (Fasta) | MSRSKRDNNF YSVEIADSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60 FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120 MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180 MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC LKILFPGRDY IDQWNKVIEQ 240 LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300 MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360 MDLEERTKNG VIRGQPSPLG AAVINGSQHP VSSPSVNDMS SMSTDPTLAS D 412 |
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Database | Annotation |
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CTD (Curated) (count: 10) (view all) | MESH:D002471
; Cell Transformation, Neoplastic MESH:D001651 ; Cholestasis, Extrahepatic MESH:D003876 ; Dermatitis, Atopic MESH:D004195 ; Disease Models, Animal MESH:D006930 ; Hyperalgesia MESH:D017114 ; Liver Failure, Acute |
PTM | Modification Sites |
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Phosphorylation (count: 4) | 179 LARTAGTSFMMTPYV dbPAF
183 AGTSFMMTPYVVTRY dbPAF 185 TSFMMTPYVVTRYYR dbPAF 188 MMTPYVVTRYYRAPE dbPAF |
Acetylation (count: 1) | 308 MLVIDASKRISVDEA PLMD |