Tag | Content |
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UniProt Accession | MAPK2_HUMAN; P49137; |
Entrez ID | 9261 |
GenBank Protein ID | NM_004759.4; NM_032960.3; |
GenBank Nucleotide ID | NP_004750.1; NP_116584.2; |
Protein Name | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) |
Gene Name | MAPKAPK2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, K(view all) |
Sequence (Fasta) | MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII 60 DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI 120 VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI 180 NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY 240 DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM 300 LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL 360 ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH 401 |
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Database | Annotation |
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GWASdb (count: 3) | rs10863787; Suicide attempts in bipolar disorder; bipolar disorder
rs12060808; Suicide attempts in bipolar disorder; bipolar disorder rs4548444; Blood Pressure; hypertension |
PTM | Modification Sites |
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Phosphorylation (count: 23) (view all) | 206 PNAILKLTDFGFAKE dbPAF
214 DFGFAKETTSHNSLT dbPAF 215 FGFAKETTSHNSLTT dbPAF 219 KETTSHNSLTTPCYT dbPAF 221 TTSHNSLTTPCYTPY dbPAF 222 TSHNSLTTPCYTPYY dbPAF |
Acetylation (count: 2) | 64 NAIIDDYKVTSQVLG PLMD
84 KVLQIFNKRTQEKFA PLMD |
Ubiquitination (count: 5) | 100 KMLQDCPKARREVEL PLMD
307 MLIRNLLKTEPTQRM PLMD 353 KERWEDVKEEMTSAL PLMD 371 RVDYEQIKIKKIEDA PLMD 84 KVLQIFNKRTQEKFA PLMD |
Sumoylation (count: 1) | 353 KERWEDVKEEMTSAL PLMD |
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