P49137

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession MAPK2_HUMAN; P49137;
Entrez ID 9261
GenBank Protein ID NM_004759.4; NM_032960.3;
GenBank Nucleotide ID NP_004750.1; NP_116584.2;
Protein Name MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)
Gene Name MAPKAPK2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionStress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, K(view all)
Sequence
(Fasta)
MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII 60
DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI 120
VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI 180
NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY 240
DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM 300
LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL 360
ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH 401

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationPancreatic cancer/carcinoma/adenocarcinomaD17131308
[Reference]: Furthermore treatment of pancreatic cancer cells with DC increases protein levels of Bax and phosphorylation of members of the p38MAPK pathway such as p38MAPK, MKK3/6 and MAPKAPK4.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 3)
rs10863787; Suicide attempts in bipolar disorder; bipolar disorder
rs12060808; Suicide attempts in bipolar disorder; bipolar disorder
rs4548444; Blood Pressure; hypertension

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 23)
(view all)
206       PNAILKLTDFGFAKE     dbPAF
214       DFGFAKETTSHNSLT     dbPAF
215       FGFAKETTSHNSLTT     dbPAF
219       KETTSHNSLTTPCYT     dbPAF
221       TTSHNSLTTPCYTPY     dbPAF
222       TSHNSLTTPCYTPYY     dbPAF
Acetylation
(count: 2)
64        NAIIDDYKVTSQVLG     PLMD
84        KVLQIFNKRTQEKFA     PLMD
Ubiquitination
(count: 5)
100       KMLQDCPKARREVEL     PLMD
307       MLIRNLLKTEPTQRM     PLMD
353       KERWEDVKEEMTSAL     PLMD
371       RVDYEQIKIKKIEDA     PLMD
84        KVLQIFNKRTQEKFA     PLMD
Sumoylation
(count: 1)
353       KERWEDVKEEMTSAL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource