P49116

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession NR2C2_HUMAN; P49116;
Entrez ID 7182
GenBank Protein ID NM_001291694.1; NM_003298.4; XM_017007120.1;
GenBank Nucleotide ID NP_001278623.1; NP_003289.2; XP_016862609.1;
Protein Name Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
Gene Name NR2C2; TAK1; TR4
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionOrphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Sequence
(Fasta)		MTSPSPRIQI ISTDSAVASP QRIQIVTDQQ TGQKIQIVTA VDASGSPKQQ FILTSPDGAG 60
TGKVILASPE TSSAKQLIFT TSDNLVPGRI QIVTDSASVE RLLGKTDVQR PQVVEYCVVC 120
GDKASGRHYG AVSCEGCKGF FKRSVRKNLT YSCRSNQDCI INKHHRNRCQ FCRLKKCLEM 180
GMKMESVQSE RKPFDVQREK PSNCAASTEK IYIRKDLRSP LIATPTFVAD KDGARQTGLL 240
DPGMLVNIQQ PLIREDGTVL LATDSKAETS QGALGTLANV VTSLANLSES LNNGDTSEIQ 300
PEDQSASEIT RAFDTLAKAL NTTDSSSSPS LADGIDTSGG GSIHVISRDQ STPIIEVEGP 360
LLSDTHVTFK LTMPSPMPEY LNVHYICESA SRLLFLSMHW ARSIPAFQAL GQDCNTSLVR 420
ACWNELFTLG LAQCAQVMSL STILAAIVNH LQNSIQEDKL SGDRIKQVME HIWKLQEFCN 480
SMAKLDIDGY EYAYLKAIVL FSPDHPGLTS TSQIEKFQEK AQMELQDYVQ KTYSEDTYRL 540
ARILVRLPAL RLMSSNITEE LFFTGLIGNV SIDSIIPYIL KMETAEYNGQ ITGASL 597

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationAlzheimer's diseaseC23844119
[Reference]: In this study, we have investigated the effect of UBB(+1) on proinflammatory signaling such as interleukin-1 (IL-1) and tumor necrosis factor- (TNF-) in human astrocytes.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D004715 ; Endometriosis
GWASdb
(count: 11)
(view all)		rs13097792; Elbow pain; heart disease
rs13097792; Weight; obesity
rs10510434; Suicide attempts in bipolar disorder; bipolar disorder
rs17040623; Suicide attempts in bipolar disorder; bipolar disorder
rs9839660; Suicide attempts in bipolar disorder; bipolar disorder
rs2164358; HIV-1 viral setpoint; Human immunodeficiency virus infectious disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 23)
(view all)		 116       QRPQVVEYCVVCGDK     dbPAF
12        SPRIQIISTDSAVAS     dbPAF
13        PRIQIISTDSAVASP     dbPAF
15        IQIISTDSAVASPQR     dbPAF
19        STDSAVASPQRIQIV     dbPAF
219       YIRKDLRSPLIATPT     dbPAF
Acetylation
(count: 2)		 200       PFDVQREKPSNCAAS     PLMD
231       TPTFVADKDGARQTG     PLMD
Ubiquitination
(count: 4)		 231       TPTFVADKDGARQTG     PLMD
318       RAFDTLAKALNTTDS     PLMD
531       ELQDYVQKTYSEDTY     PLMD
63        PDGAGTGKVILASPE     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource