| Tag | Content |
|---|---|
| UniProt Accession | PAXI_HUMAN; P49023; |
| Entrez ID | 5829 |
| GenBank Protein ID | NM_001080855.2; NM_001243756.1; NM_002859.3; NM_025157.4; XM_017019743.1; |
| GenBank Nucleotide ID | NP_001074324.1; NP_001230685.1; NP_002850.2; NP_079433.3; XP_016875232.1; |
| Protein Name | Paxillin |
| Gene Name | PXN |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). |
| Sequence (Fasta) | MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG 60 TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF 120 PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL 180 YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG 240 EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG 300 RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA 360 CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH NLFSPRCYYC 420 NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA 480 RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK 540 PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C 592 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D002471
; Cell Transformation, Neoplastic MESH:D008546 ; Melanoma, Experimental MESH:D009362 ; Neoplasm Metastasis MESH:D002289 ; Carcinoma, Non-Small-Cell Lung |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 68) (view all) | 103 SVSNPQDSVGSPCSR dbPAF
106 NPQDSVGSPCSRVGE dbPAF 109 DSVGSPCSRVGEEEH dbPAF 118 VGEEEHVYSFPNKQK dbPAF 119 GEEEHVYSFPNKQKS dbPAF 126 SFPNKQKSAEPSPTV dbPAF |
| Acetylation (count: 4) | 355 LGVATVAKGVCGACK PLMD
540 SLCSGCQKPITGRCI PLMD 553 CITAMAKKFHPEHFV PLMD 574 QLNKGTFKEQNDKPY PLMD |
| Ubiquitination (count: 5) | 123 HVYSFPNKQKSAEPS PLMD
277 MASLSDFKIQGLEQR PLMD 355 LGVATVAKGVCGACK PLMD 540 SLCSGCQKPITGRCI PLMD 579 TFKEQNDKPYCQNCF PLMD |
| Malonylation (count: 1) | 570 FCLKQLNKGTFKEQN PLMD |