P49023

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PAXI_HUMAN; P49023;
Entrez ID 5829
GenBank Protein ID NM_001080855.2; NM_001243756.1; NM_002859.3; NM_025157.4; XM_017019743.1;
GenBank Nucleotide ID NP_001074324.1; NP_001230685.1; NP_002850.2; NP_079433.3; XP_016875232.1;
Protein Name Paxillin
Gene Name PXN
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
Sequence
(Fasta)
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG 60
TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF 120
PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL 180
YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG 240
EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG 300
RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA 360
CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH NLFSPRCYYC 420
NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA 480
RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK 540
PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C 592

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationNon-small cell lung cancer/carcinomaP24096476
[Reference]: Patients with tumors positive for PXN, phosphorylated PXN, phosphorylated ERK and Bcl-2 more commonly showed a poorer response to cisplatin-based chemotherapy than did patients with negative tumors
2PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaP11287749
[Reference]: Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells.
3PhosphorylationBreast cancer/tumor/carcinomaU10602479
[Reference]: We report that HRG stimulation of non-invasive breast cancer cells resulted in stimulation of p38 mitogen-activated protein kinase (p38MAPK), extracellular signal-regulated kinases (ERK) and PI-3K, and a concurrent unexpected increase in the level of paxillin phosphorylation on serine residue which was sensitive to protein-phosphatase 2b but not to protein tyrosine phosphatase 1.
4Tyrosine PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/Hepatomatumor tissuePY3123524339
[Reference]: PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2
5Tyrosine PhosphorylationColon cancer/carcinomaUY8820133777
[Reference]: PTPRT knockout mice that we generated exhibit increased levels of colonic paxillin phosphorylation at residue Y88 and are highly susceptible to carcinogen azoxymethane-induced colon tumor, providing critical in vivo evidence that PTPRT normally functions as a tumor suppressor.
6Tyrosine PhosphorylationBladder cancerPY11822617682
[Reference]: Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells
7Tyrosine PhosphorylationOral squamous cell carcinomacell linePY11823375593
[Reference]: Depletion of CRT inhibits migration of oral cancer cells presumably due to decreased activity of FAK and MMP-2/MMP-9
8Serine PhosphorylationNon-small cell lung cancer/carcinomaPS12623549785
[Reference]: ERK2 but not ERK1 is shown to be responsible for paxillin serine 126 phosphorylation and its increased turnover at focal adhesions
9Serine PhosphorylationBreast cancer/tumor/carcinomaPS17822700880
[Reference]: MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis
10Serine PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/Hepatomatumor tissuePS17823524339
[Reference]: PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2
11Serine PhosphorylationPancreatic cancer/carcinoma/adenocarcinomaPS17823890137
[Reference]: WNT5A/JNK signaling regulates pancreatic cancer cells migration by Phosphorylating Paxillin