P48357

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession LEPR_HUMAN; P48357;
Entrez ID 3953
GenBank Protein ID NM_001003679.3; NM_001003680.3; NM_001198687.1; NM_001198688.1; NM_001198689.1; NM_002303.5;
GenBank Nucleotide ID NP_001003679.1; NP_001003680.1; NP_001185616.1; NP_001185617.1; NP_001185618.1; NP_002294.2;
Protein Name Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)
Gene Name LEPR; DB; OBR
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionReceptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324(view all)
Sequence
(Fasta)
MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNS 60
NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS LCADNIEGKT FVSTVNSLVF 120
QQIDANWNIQ CWLKGDLKLF ICYVESLFKN LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS 180
FQMVHCNCSV HECCECLVPV PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP 240
LGLHMEITDD GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP 300
GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF HCIYKKENKI 360
VPSKEIVWWM NLAEKIPQSQ YDVVSDHVSK VTFFNLNETK PRGKFTYDAV YCCNEHECHH 420
RYAELYVIDV NINISCETDG YLTKMTCRWS TSTIQSLAES TLQLRYHRSS LYCSDIPSIH 480
PISEPKDCYL QSDGFYECIF QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP 540
SSVKAEITIN IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV 600
PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN GDTMKKEKNV 660
TLLWKPLMKN DSLCSVQRYV INHHTSCNGT WSEDVGNHTK FTFLWTEQAH TVTVLAINSI 720
GASVANFNLT FSWPMSKVNI VQSLSAYPLN SSCVIVSWIL SPSDYKLMYF IIEWKNLNED 780
GEIKWLRISS SVKKYYIHDH FIPIEKYQFS LYPIFMEGVG KPKIINSFTQ DDIEKHQSDA 840
GLYVIVPVII SSSILLLGTL LISHQRMKKL FWEDVPNPKN CSWAQGLNFQ KPETFEHLFI 900
KHTASVTCGP LLLEPETISE DISVDTSWKN KDEMMPTTVV SLLSTTDLEK GSVCISDQFN 960
SVNFSEAEGT EVTYEDESQR QPFVKYATLI SNSKPSETGE EQGLINSSVT KCFSSKNSPL 1020
KDSFSNSSWE IEAQAFFILS DQHPNIISPH LTFSEGLDEL LKLEGNFPEE NNDKKSIYYL 1080
GVTSIKKRES GVLLTDKSRV SCPFPAPCLF TDIRVLQDSC SHFVENNINL GTSSKKTFAS 1140
YMPQFQTCST QTHKIMENKM CDLTV 1166

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationColon cancer/carcinomaUY114121166956
[Reference]: However, increased expression and activation of the leptin receptor, as indicated by findings such as the phosphorylation of Tyr 1141, was observed in the colorectal adenoma tissues.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 33)
(view all)
MESH:D000419 ; Albuminuria
MESH:D001943 ; Breast Neoplasms
MESH:D016640 ; Diabetes, Gestational
MESH:D003920 ; Diabetes Mellitus
MESH:D003921 ; Diabetes Mellitus, Experimental
MESH:D003924 ; Diabetes Mellitus, Type 2
DisGeNet (Curated)
(count: 58)
(view all)
C0001807; Aggressive behavior
C0001925; Albuminuria
C0011849; Diabetes Mellitus
C0011853; Diabetes Mellitus, Experimental
C0011860; Diabetes Mellitus, Non-Insulin-Dependent
C0011882; Diabetic Neuropathies
GWASdb
(count: 186)
(view all)
rs9436735; LDL cholesterol; atherosclerosis|coronary artery disease
rs9436735; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs9436735; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease
rs9436297; Glioma (high-grade); brain glioma
rs9436299; C-reactive protein; metabolic syndrome X|type 2 diabetes mellitus|hypertension|myocardial infarction
rs17127608; LDL cholesterol; atherosclerosis|coronary artery disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 18)
(view all)
1078      NNDKKSIYYLGVTSI     dbPAF
1079      NDKKSIYYLGVTSIK     dbPAF
1090      TSIKKRESGVLLTDK     dbPAF
1141      SKKTFASYMPQFQTC     dbPAF
172       LPEVLEDSPLVPQKG     dbPAF
208       PTAKLNDTLLMCLKI     dbPAF
Ubiquitination
(count: 4)
658       GDTMKKEKNVTLLWK     PLMD
821       IFMEGVGKPKIINSF     PLMD
879       WEDVPNPKNCSWAQG     PLMD
891       AQGLNFQKPETFEHL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
O14543P48357HPRD
O60674P48357HPRD; IntAct
P07998P48357BioGRID
P40763P48357HPRD
P48357P52333IntAct
P48357Q13526HPRD; IntAct; MINT
P48357Q8WXI7BioGRID