Tag | Content |
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UniProt Accession | LEPR_MOUSE; P48356; |
Entrez ID | 16847 |
GenBank Protein ID | NM_001122899.1; NM_010704.2; NM_146146.2; |
GenBank Nucleotide ID | NP_001116371.1; NP_034834.1; NP_666258.2; |
Protein Name | Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295) |
Gene Name | Lepr; Db; Obr |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:25383904, PubMed:11923481, PubMed:11861497). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of h(view all) |
Sequence (Fasta) | MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP AGAPNNASAL 60 KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS ALTDNTEGKT LASVVKASVF 120 RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN PFKNYDSKVH LLYDLPEVID DSPLPPLKDS 180 FQTVQCNCSL RGCECHVPVP RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 240 GLHMEVTDDG NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS 300 SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC IYKNENQIIS 360 SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 420 AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT 480 SEPKNCVLQR DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 540 VKAEITVNTG LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD 600 LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD VTKKERNVTL 660 LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT FLWTEPAHTV TVLAVNSLGA 720 SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS CVILSWTLSP DDYSLLYLVI EWKILNEDDG 780 MKWLRIPSNV KKFYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL 840 YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH 900 AESVIFGPLL LEPEPISEEI SVDTAWKNKD EMVPAAMVSL LLTTPDPESS SICISDQCNS 960 ANFSGSQSTQ VTCEDECQRQ PSVKYATLVS NDKLVETDEE QGFIHSPVSN CISSNHSPLR 1020 QSFSSSSWET EAQTFFLLSD QQPTMISPQL SFSGLDELLE LEGSFPEENH REKSVCYLGV 1080 TSVNRRESGV LLTGEAGILC TFPAQCLFSD IRILQERCSH FVENNLSLGT SGENFVPYMP 1140 QFQTCSTHSH KIMENKMCDL TV 1163 |
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Database | Annotation |
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CTD (Curated) (count: 33) (view all) | MESH:D000419
; Albuminuria MESH:D001943 ; Breast Neoplasms MESH:D016640 ; Diabetes, Gestational MESH:D003920 ; Diabetes Mellitus MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D003924 ; Diabetes Mellitus, Type 2 |
PTM | Modification Sites |
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Phosphorylation (count: 7) (view all) | 1077 HREKSVCYLGVTSVN dbPAF
1138 SGENFVPYMPQFQTC dbPAF 433 IDVNINISCETDGYL dbPAF 436 NINISCETDGYLTKM dbPAF 439 ISCETDGYLTKMTCR dbPAF 880 VPNPKNCSWAQGLNF dbPAF |