Tag | Content |
---|---|
UniProt Accession | KSYK_MOUSE; P48025; |
Entrez ID | 20963 |
GenBank Protein ID | NM_001198977.1; NM_011518.2; XM_006516895.3; |
GenBank Nucleotide ID | NP_001185906.1; NP_035648.2; XP_006516958.1; |
Protein Name | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) |
Gene Name | Syk; ptk72; Sykb |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the r(view all) |
Sequence (Fasta) | MAGSAVDSAN HLTYFFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF ALSVAHNRKA 60 HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPDGLIC LLKKPFNRPP GVQPKTGPFE 120 DLKENLIREY VKQTWNLQGQ ALEQAIISQK PQLEKLIATT AHEKMPWFHG NISRDESEQT 180 VLIGSKTNGK FLIRARDNSG SYALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV 240 EHYSYKPDGL LRVLTVPCQK IGAQMGHPGS PNAHPVTWSP GGIISRIKSY SFPKPGHKKP 300 APPQGSRPES TVSFNPYEPT GGPWGPDRGL QREALPMDTE VYESPYADPE EIRPKEVYLD 360 RSLLTLEDNE LGSGNFGTVK KGYYQMKKVV KTVAVKILKN EANDPALKDE LLAEANVMQQ 420 LDNPYIVRMI GICEAESWML VMEMAELGPL NKYLQQNRHI KDKNIIELVH QVSMGMKYLE 480 ESNFVHRDLA ARNVLLVTQH YAKISDFGLS KALRADENYY KAQTHGKWPV KWYAPECINY 540 YKFSSKSDVW SFGVLMWEAF SYGQKPYRGM KGSEVTAMLE KGERMGCPAG CPREMYDLMN 600 LCWTYDVENR PGFTAVELRL RNYYYDVVN |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 2) | MESH:D008545
; Melanoma MESH:D008654 ; Mesothelioma |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 21) (view all) | 130 KENLIREYVKQTWNL dbPAF
202 ARDNSGSYALCLLHE dbPAF 270 AQMGHPGSPNAHPVT dbPAF 277 SPNAHPVTWSPGGII dbPAF 279 NAHPVTWSPGGIISR dbPAF 290 IISRIKSYSFPKPGH dbPAF |