P47941

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession CRKL_MOUSE; P47941;
Entrez ID 12929
GenBank Protein ID NM_001277231.1; NM_007764.5;
GenBank Nucleotide ID NP_001264160.1; NP_031790.2;
Protein Name Crk-like protein
Gene Name Crkl; Crkol
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionMay mediate the transduction of intracellular signals.
Sequence
(Fasta)
MSSARFDSSD RSAWYMGPVT RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 60
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPV GSVSAPNLPT 120
AEENLEYVRT LYDFPGNDAE DLPFKKGELL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK 180
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPTVA STPGAAINPL PSTQNGPVFA 240
KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD 300
DNE 304

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationPhiladelphia-positive leukemiaP12082638
[Reference]: Multiple independent studies have implicated Crkl, a small adapter protein, in transduction of oncogenic signals of Bcr/Abl and Crkl tyrosine-phosphorylation is used as a diagnostic tool for Philadelphia-positive leukemia.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)
MESH:D004062 ; DiGeorge Syndrome

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 25)
(view all)
105       LIEPAPRYPSPPVGS     dbPAF
107       EPAPRYPSPPVGSVS     dbPAF
112       YPSPPVGSVSAPNLP     dbPAF
114       SPPVGSVSAPNLPTA     dbPAF
127       TAEENLEYVRTLYDF     dbPAF
130       ENLEYVRTLYDFPGN     dbPAF
Ubiquitination
(count: 1)
180       IPVPYVEKLVRSSPH     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource