P46734

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MP2K3_HUMAN; P46734;
Entrez ID 5606
GenBank Protein ID NM_001316332.1; NM_002756.4; NM_145109.2; XM_005256723.2; XM_011523959.1; XM_017024858.1; XM_017024859.1;
GenBank Nucleotide ID NP_001303261.1; NP_002747.2; NP_659731.1; XP_005256780.1; XP_011522261.1; XP_016880347.1; XP_016880348.1;
Protein Name Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene Name MAP2K3; MEK3; MKK3; PRKMK3; SKK2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionDual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
Sequence
(Fasta)		MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE 60
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC 120
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL 180
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 240
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 300
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS 348

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationPancreatic cancer/carcinoma/adenocarcinomaD17131308
[Reference]: Furthermore treatment of pancreatic cancer cells with DC increases protein levels of Bax and phosphorylation of members of the p38MAPK pathway such as p38MAPK, MKK3/6 and MAPKAPK3.

※ Disease Cross-ref Annotation

DatabaseAnnotation
HGMD
(count: 1)		CM071857; Protein kinase deficiency; Missense/nonsense
GWASdb
(count: 3)		rs3760201; Attention deficit hyperactivity disorder; attention deficit hyperactivity disorder
rs9901404; Body mass index; obesity
rs6587138; Type 2 diabetes; type 2 diabetes mellitus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 17)
(view all)		 101       RIRATVNSQEQKRLL     dbPAF
15        QPASMPQSKGKSKRK     dbPAF
212       KMCDFGISGYLVDSV     dbPAF
214       CDFGISGYLVDSVAK     dbPAF
218       ISGYLVDSVAKTMDA     dbPAF
222       LVDSVAKTMDAGCKP     dbPAF
Acetylation
(count: 2)		 183       ALEHLHSKLSVIHRD     PLMD
32        LRISCMSKPPAPNPT     PLMD
Ubiquitination
(count: 11)
(view all)		 16        PASMPQSKGKSKRKK     PLMD
183       ALEHLHSKLSVIHRD     PLMD
192       SVIHRDVKPSNVLIN     PLMD
200       PSNVLINKEGHVKMC     PLMD
228       KTMDAGCKPYMAPER     PLMD
243       INPELNQKGYNVKSD     PLMD
Sumoylation
(count: 1)		 192       SVIHRDVKPSNVLIN     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource