P46152

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession GATA4_RAT; P46152;
Entrez ID 54254
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Transcription factor GATA-4 (DNA-binding protein GATA-GT2) (GATA-binding factor 4)
Gene Name Gata4
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionTranscriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (By similarity).
Sequence
(Fasta)		MYQSLAMAAN HGPPPGAYEA GGPGAFMHSA GAASSPVYVP TPRVPSSVLG LSYLQGGGSG 60
AASGATSGGS SGAGPSGAGP GTQQGSPGWS QAGAEGAAYT PPPVSPRFSF PGTTGSLAAA 120
AAAAAAREAA AYSSSGGAAG AGLAGREQYG RPGFAGSYSS PYPAYMADVG ASWAAAAAAS 180
AGPFDSPVLH SLPGRANPAR HPNLDMFDDF SEGRECVNCG AMSTPLWRRD GTGHYLCNAC 240
GLYHKMNGIN RPLIKPQRRL SASRRVGLSC ANCQTTTTTL WRRNAEGEPV CNACGLYMKL 300
HGVPRPLAMR KEGIQTRKRK PKNLNKSKTP AGPPGESLPP SSGASSNSSN ATSSSSSSEE 360
MRPIKTEPGL SSHYGHSSSM SQTFSTVSGH GSSIHPVLSA LKLSPQGYPS PVTQTSQASS 420
KQDSWNSLVL ADSHGDIITA 441

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationHeart failureUS10522227582
[Reference]: Together with GATA4 phosphorylation at Ser105 by ERK1/2, our findings show dual phosphorylation of GATA4 by the ERK-RSK cascade and suggest that MSK and RSK have distinct effects in PE-induced cardiac hypertrophic response.
2Serine PhosphorylationHeart failureUS26122227582
[Reference]: Inhibition of RSK using the small molecule SL0101 abrogated GATA4 phosphorylation at Ser261, ultimately leading to a repression of fetal cardiac genes.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 11)
(view all)		MESH:D000437 ; Alcoholism
MESH:C538263 ; Atrial septal defect 2
MESH:C562831 ; Atrioventricular Septal Defect
MESH:D006332 ; Cardiomegaly
MESH:D015179 ; Colorectal Neoplasms
MESH:D006345 ; Heart Septal Defects, Ventricular

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 2)		 105       AYTPPPVSPRFSFPG     dbPAF
261       IKPQRRLSASRRVGL     dbPAF
Acetylation
(count: 1)		 421       QTSQASSKQDSWNSL     PLMD