P46109

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession CRKL_HUMAN; P46109;
Entrez ID 1399
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Crk-like protein
Gene Name CRKL
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay mediate the transduction of intracellular signals.
Sequence
(Fasta)
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 60
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT 120
AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK 180
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA 240
KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD 300
ENE 304

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationLeukemiaP15864744
[Reference]: Furthermore, denbinobin significantly suppressed the expression of Bcr-Abl and phosphorylation of CrkL, a crucial tyrosine kinase and an adaptor protein in chronic myeloid leukemia, respectively.
2PhosphorylationChronic myelogenous leukemia/Chronic myeloid leukemiaU21429397
[Reference]: The level of p-CRKL % and MFI in newly diagnosed group was higher than that in imatinib responded group (P = 0.000; P = 0.01) and also higher in imatinib-effective group than in imatinib-resistant group (P = 0.000; P = 0.02).

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)
MESH:D004062 ; DiGeorge Syndrome
DisGeNet (Curated)
(count: 35)
(view all)
C0012236; DiGeorge Syndrome
C0014306; Enophthalmos
C0015934; Fetal Growth Retardation
C0016202; Flatfoot
C0021296; Infant, Small for Gestational Age
C0023015; Language Disorders
GWASdb
(count: 1)
rs8142366; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 30)
(view all)
105       LIEPAPRYPSPPMGS     dbPAF
107       EPAPRYPSPPMGSVS     dbPAF
112       YPSPPMGSVSAPNLP     dbPAF
114       SPPMGSVSAPNLPTA     dbPAF
127       TAEDNLEYVRTLYDF     dbPAF
130       DNLEYVRTLYDFPGN     dbPAF
Acetylation
(count: 2)
145       DAEDLPFKKGEILVI     PLMD
253       RVPCAYDKTALALEV     PLMD
Ubiquitination
(count: 2)
180       IPVPYVEKLVRSSPH     PLMD
292       LFPFTHVKIFDPQNP     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
A7KAX9P46109HPRD
O00459P46109HPRD
O14654P46109HPRD
O15162P46109IntAct
O15197P46109HPRD
O15230P46109IntAct
O43294P46109HPRD
O43516P46109HPRD
O75095P46109IntAct
O75553P46109HPRD
P00519P46109MINT;HPRD
P00533P46109MINT
P04626P46109MINT
P05556P46109DIP;HPRD
P06213P46109HPRD; IntAct
P07948P46109HPRD; MINT
P08069P46109HPRD
P10721P46109HPRD
P11274P46109HPRD
P12314P46109HPRD
P16234P46109HPRD
P17181P46109HPRD
P19235P46109HPRD
P21860P46109MINT
P22681P46109HPRD; MINT
P25490P46109IntAct
P27986P46109HPRD; MINT
P28799P46109IntAct
P28906P46109HPRD
P29353P46109HPRD
P29597P46109HPRD
P41212P46109HPRD
P42229P46109HPRD
P42768P46109HPRD
P43405P46109HPRD
P45983P46109MINT
P46108P46109HPRD
P46109P46109DIP
P46109P49023HPRD
P46109P51692HPRD
P46109P56945HPRD
P46109P62899IntAct
P46109P62993HPRD
P46109Q04721IntAct
P46109Q06124HPRD
P46109Q06278IntAct
P46109Q07666IntAct
P46109Q07889HPRD
P46109Q07890HPRD
P46109Q12774IntAct
P46109Q13191HPRD
P46109Q13323IntAct
P46109Q13480MINT;HPRD
P46109Q13905MINT;HPRD
P46109Q14511HPRD
P46109Q15303MINT
P46109Q5SVJ7MINT
P46109Q63HR2IntAct
P46109Q68DK7IntAct
P46109Q8IXK0IntAct
P46109Q8IZP0MINT
P46109Q8ND30IntAct
P46109Q8WV28HPRD
P46109Q92608HPRD
P46109Q92835HPRD
P46109Q92918HPRD; IntAct
P46109Q93009IntAct
P46109Q99704HPRD
P46109Q9BTA9IntAct
P46109Q9BYB0IntAct
P46109Q9H0R8IntAct
P46109Q9H706IntAct
P46109Q9HB21IntAct
P46109Q9HCN6DIP
P46109Q9UI08HPRD
P46109Q9ULH0HPRD; MINT
P46109Q9UQC2HPRD
P46109Q9Y2S0IntAct
P46109Q9Y4K4HPRD; IntAct