| Tag | Content |
|---|---|
| UniProt Accession | CRK_HUMAN; P46108; |
| Entrez ID | 1398 |
| GenBank Protein ID | NM_005206.4; NM_016823.3; |
| GenBank Nucleotide ID | NP_005197.3; NP_058431.2; |
| Protein Name | Adapter molecule crk (Proto-oncogene c-Crk) (p38) |
| Gene Name | CRK |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
| Sequence (Fasta) | MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 60 IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 120 SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 180 MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA 240 RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 300 EDFS 305 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D017202 ; Myocardial Ischemia |
| DisGeNet (Curated) (count: 1) | C0151744; Myocardial Ischemia |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 29) (view all) | 108 LEFYKIHYLDTTTLI dbPAF
111 YKIHYLDTTTLIEPV dbPAF 112 KIHYLDTTTLIEPVS dbPAF 113 IHYLDTTTLIEPVSR dbPAF 119 TTLIEPVSRSRQGSG dbPAF 121 LIEPVSRSRQGSGVI dbPAF |
| Acetylation (count: 2) | 253 RVPNAYDKTALALEV PLMD
282 WEGECNGKRGHFPFT PLMD |