Tag | Content |
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UniProt Accession | MP2K4_HUMAN; P45985; |
Entrez ID | 6416 |
GenBank Protein ID | NM_001281435.1; NM_003010.3; |
GenBank Nucleotide ID | NP_001268364.1; NP_003001.1; |
Protein Name | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) |
Gene Name | MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr(view all) |
Sequence (Fasta) | MAAPSPSGGG GSGGGSGSGT PGPVGSPAPG HPAVSSMQGK RKALKLNFAN PPFKSTARFT 60 LNPNPTGVQN PHIERLRTHS IESSGKLKIS PEQHWDFTAE DLKDLGEIGR GAYGSVNKMV 120 HKPSGQIMAV KRIRSTVDEK EQKQLLMDLD VVMRSSDCPY IVQFYGALFR EGDCWICMEL 180 MSTSFDKFYK YVYSVLDDVI PEEILGKITL ATVKALNHLK ENLKIIHRDI KPSNILLDRS 240 GNIKLCDFGI SGQLVDSIAK TRDAGCRPYM APERIDPSAS RQGYDVRSDV WSLGITLYEL 300 ATGRFPYPKW NSVFDQLTQV VKGDPPQLSN SEEREFSPSF INFVNLCLTK DESKRPKYKE 360 LLKHPFILMY EERAVEVACY VCKILDQMPA TPSSPMYVD |
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Database | Annotation |
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Cancer Gene Census | pancreatic, breast, colorectal |
GWASdb (count: 4) | rs7216812; Information processing speed; cognitive disorder
rs8069300; Urinary metabolites; kidney disease rs9788973; Response to platinum-based chemotherapy in non-small-cell lung cancer; non-small cell lung carcinoma rs10432016; Urinary metabolites; kidney disease |
PTM | Modification Sites |
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Phosphorylation (count: 17) (view all) | 18 GSGGGSGSGTPGPVG dbPAF
20 GGGSGSGTPGPVGSP dbPAF 257 ISGQLVDSIAKTRDA dbPAF 26 GTPGPVGSPAPGHPA dbPAF 261 LVDSIAKTRDAGCRP dbPAF 35 APGHPAVSSMQGKRK dbPAF |
Acetylation (count: 1) | 131 SGQIMAVKRIRSTVD PLMD |
Ubiquitination (count: 1) | 231 KIIHRDIKPSNILLD PLMD |
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