Tag | Content |
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UniProt Accession | MK08_HUMAN; P45983; |
Entrez ID | 5599 |
GenBank Protein ID | NM_001278547.1; NM_001278548.1; NM_001323302.1; NM_001323321.1; NM_001323322.1; NM_001323323.1; NM_001323324.1; NM_001323325.1; NM_001323326.1; NM_001323327.1; NM_001323328.1; NM_001323329.1; NM_001323330.1; NM_001323331.1; NM_139046.3; NM_139049.3; |
GenBank Nucleotide ID | NP_001265476.1; NP_001265477.1; NP_001310231.1; NP_001310250.1; NP_001310251.1; NP_001310252.1; NP_001310253.1; NP_001310254.1; NP_001310255.1; NP_001310256.1; NP_001310257.1; NP_001310258.1; NP_001310259.1; NP_001310260.1; NP_620634.1; NP_620637.1; |
Protein Name | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) |
Gene Name | MAPK8; JNK1; PRKM8; SAPK1; SAPK1C |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such(view all) |
Sequence (Fasta) | MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60 FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120 MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180 MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ 240 LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300 MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360 MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA 420 GPLGCCR 428 |
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Database | Annotation |
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CTD (Curated) (count: 10) (view all) | MESH:D002471
; Cell Transformation, Neoplastic MESH:D001651 ; Cholestasis, Extrahepatic MESH:D003876 ; Dermatitis, Atopic MESH:D004195 ; Disease Models, Animal MESH:D006930 ; Hyperalgesia MESH:D017114 ; Liver Failure, Acute |
GWASdb (count: 2) | rs10857561; Salmonella-induced pyroptosis; Null
rs2289805; Urinary metabolites; kidney disease |
PTM | Modification Sites |
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Phosphorylation (count: 15) (view all) | 155 IHRDLKPSNIVVKSD dbPAF
178 GLARTAGTSFMMTPY dbPAF 179 LARTAGTSFMMTPYV dbPAF 183 AGTSFMMTPYVVTRY dbPAF 185 TSFMMTPYVVTRYYR dbPAF 188 MMTPYVVTRYYRAPE dbPAF |
Acetylation (count: 1) | 308 MLVIDASKRISVDEA PLMD |
Ubiquitination (count: 11) (view all) | 153 GIIHRDLKPSNIVVK PLMD
160 KPSNIVVKSDCTLKI PLMD 166 VKSDCTLKILDFGLA PLMD 251 PCPEFMKKLQPTVRT PLMD 265 TYVENRPKYAGYSFE PLMD 288 PADSEHNKLKASQAR PLMD |
Glycation (count: 1) | 288 PADSEHNKLKASQAR PLMD |