P45379

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession TNNT2_HUMAN; P45379;
Entrez ID 7139
GenBank Protein ID NM_000364.3; NM_001001430.2; NM_001001431.2; NM_001001432.2; NM_001276345.1; NM_001276346.1; NM_001276347.1; XM_006711508.3; XM_011509938.2; XM_011509939.1; XM_011509940.2; XM_011509942.2; XM_011509943.2; XM_017002217.1;
GenBank Nucleotide ID NP_000355.2; NP_001001430.1; NP_001001431.1; NP_001001432.1; NP_001263274.1; NP_001263275.1; NP_001263276.1; XP_006711571.1; XP_011508240.1; XP_011508241.1; XP_011508242.1; XP_011508244.1; XP_011508245.1; XP_016857706.1;
Protein Name Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)
Gene Name TNNT2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTroponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence
(Fasta)
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE TRAEEDEEEE 60
EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF 120
ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED 180
EARKKKALSN MMHFGGYIQK QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR 240
EKAKELWQSI YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK 299

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationHeart failureDS20820418543
[Reference]: Using a rat model of MI and phosphoproteomic technology, we discovered that remodelling is associated with decreased levels of myocardial and plasma serine(208)-phosphorylated troponin T (TnT).

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 20)
(view all)
MESH:D054058 ; Acute Coronary Syndrome
MESH:D006332 ; Cardiomegaly
MESH:D009202 ; Cardiomyopathies
MESH:D002311 ; Cardiomyopathy, Dilated
MESH:C563306 ; Cardiomyopathy, Dilated, 1D
MESH:C566171 ; Cardiomyopathy, Familial Hypertrophic, 2
GWASdb
(count: 8)
(view all)
rs2275863; Alcoholism (heaviness of drinking); alcohol dependence
rs3729842; Type 2 diabetes; type 2 diabetes mellitus
rs6427901; Amyotrophic lateral sclerosis (sporadic); amyotrophic lateral sclerosis
rs868407; Coronary heart disease; coronary artery disease
rs6663175; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs3020556; Cardiac Troponin-T levels; congestive heart failure|coronary artery disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 9)
(view all)
189       ARKKKALSNMMHFGG     dbPAF
197       NMMHFGGYIQKQAQT     dbPAF
2         ******MSDIEEVVE     dbPAF
204       YIQKQAQTERKSGKR     dbPAF
208       QAQTERKSGKRQTER     dbPAF
213       RKSGKRQTEREKKKK     dbPAF
Glycation
(count: 2)
185       AEDEARKKKALSNMM     PLMD
186       EDEARKKKALSNMMH     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource