Tag | Content |
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UniProt Accession | KSYK_HUMAN; P43405; |
Entrez ID | 6850 |
GenBank Protein ID | NM_001135052.3; NM_001174167.2; NM_001174168.2; NM_003177.6; XM_005252147.3; XM_011518946.2; |
GenBank Nucleotide ID | NP_001128524.1; NP_001167638.1; NP_001167639.1; NP_003168.2; XP_005252204.1; XP_011517248.1; |
Protein Name | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) |
Gene Name | SYK |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the r(view all) |
Sequence (Fasta) | MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK 60 AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF 120 EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ 180 IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL 240 VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK 300 PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES PYADPEEIRP 360 KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE 420 ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM 480 GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA 540 PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE 600 MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN 636 |
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Database | Annotation |
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Cancer Gene Census | MDS, peripheral T-cell lymphoma |
CTD (Curated) (count: 2) | MESH:D008545
; Melanoma MESH:D008654 ; Mesothelioma |
GWASdb (count: 25) (view all) | rs290986; Multiple sclerosis; multiple sclerosis
rs1319677; Breast cancer; breast cancer rs12553524; Breast cancer; breast cancer rs7036417; Breast cancer; breast cancer rs12551275; Multiple complex diseases; Null rs7032733; Multiple complex diseases; Null |
PTM | Modification Sites |
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Phosphorylation (count: 42) (view all) | 131 KENLIREYVKQTWNL dbPAF
161 LEKLIATTAHEKMPW dbPAF 178 GKISREESEQIVLIG dbPAF 202 RARDNNGSYALCLLH dbPAF 203 ARDNNGSYALCLLHE dbPAF 244 LWQLVEHYSYKADGL dbPAF |
Ubiquitination (count: 3) | 517 ISDFGLSKALRADEN PLMD
577 QKPYRGMKGSEVTAM PLMD 587 EVTAMLEKGERMGCP PLMD |