Tag | Content |
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UniProt Accession | ZAP70_HUMAN; P43403; |
Entrez ID | 7535 |
GenBank Protein ID | NM_001079.3; NM_207519.1; |
GenBank Nucleotide ID | NP_001070.2; NP_997402.1; |
Protein Name | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) |
Gene Name | ZAP70; SRK |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the st(view all) |
Sequence (Fasta) | MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL VHDVRFHHFP 60 IERQLNGTYA IAGGKAHCGP AELCEFYSRD PDGLPCNLRK PCNRPSGLEP QPGVFDCLRD 120 AMVRDYVRQT WKLEGEALEQ AIISQAPQVE KLIATTAHER MPWYHSSLTR EEAERKLYSG 180 AQTDGKFLLR PRKEQGTYAL SLIYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK 240 LKADGLIYCL KEACPNSSAS NASGAAAPTL PAHPSTLTHP QRRIDTLNSD GYTPEPARIT 300 SPDKPRPMPM DTSVYESPYS DPEELKDKKL FLKRDNLLIA DIELGCGNFG SVRQGVYRMR 360 KKQIDVAIKV LKQGTEKADT EEMMREAQIM HQLDNPYIVR LIGVCQAEAL MLVMEMAGGG 420 PLHKFLVGKR EEIPVSNVAE LLHQVSMGMK YLEEKNFVHR DLAARNVLLV NRHYAKISDF 480 GLSKALGADD SYYTARSAGK WPLKWYAPEC INFRKFSSRS DVWSYGVTMW EALSYGQKPY 540 KKMKGPEVMA FIEQGKRMEC PPECPPELYA LMSDCWIYKW EDRPDFLTVE QRMRACYYSL 600 ASKVEGPPGS TQKAEAACA |
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Database | Annotation |
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CTD (Curated) (count: 5) | OMIM:617006
; AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 OMIM:269840 ; IMMUNODEFICIENCY 48 MESH:D007153 ; Immunologic Deficiency Syndromes MESH:D016511 ; Severe Combined Immunodeficiency MESH:C536780 ; T cell immunodeficiency primary |
HGMD (count: 9) (view all) | CD941817; Immunodeficiency, severe combined; Small deletions
CM994076; CD8 deficiency; Missense/nonsense CM092653; Immunodeficiency, severe combined; Missense/nonsense CM015398; Immunodeficiency, severe combined; Missense/nonsense CM003626; Immunodeficiency, severe combined; Missense/nonsense CM941410; Immunodeficiency, severe combined; Missense/nonsense |
GWASdb (count: 2) | rs11687510; Tourette syndrome; Gilles de la Tourette syndrome|obsessive-compulsive disorder|attention deficit hyperactivity disorder
rs13033383; Tourette syndrome; Gilles de la Tourette syndrome|obsessive-compulsive disorder|attention deficit hyperactivity disorder |
PTM | Modification Sites |
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Phosphorylation (count: 51) (view all) | 12 AAHLPFFYGSISRAE dbPAF
126 RDAMVRDYVRQTWKL dbPAF 164 AHERMPWYHSSLTRE dbPAF 166 ERMPWYHSSLTREEA dbPAF 167 RMPWYHSSLTREEAE dbPAF 178 EEAERKLYSGAQTDG dbPAF |
Acetylation (count: 8) (view all) | 186 SGAQTDGKFLLRPRK PLMD
217 HYLISQDKAGKYCIP PLMD 326 YSDPEELKDKKLFLK PLMD 369 KQIDVAIKVLKQGTE PLMD 372 DVAIKVLKQGTEKAD PLMD 484 ISDFGLSKALGADDS PLMD |
Ubiquitination (count: 27) (view all) | 100 GLPCNLRKPCNRPSG PLMD
132 DYVRQTWKLEGEALE PLMD 151 SQAPQVEKLIATTAH PLMD 176 TREEAERKLYSGAQT PLMD 186 SGAQTDGKFLLRPRK PLMD 193 KFLLRPRKEQGTYAL PLMD |
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