| Tag | Content |
|---|---|
| UniProt Accession | MAGA1_HUMAN; P43355; |
| Entrez ID | 4100 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen) |
| Gene Name | MAGEA1; MAGE1; MAGE1A |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. |
| Sequence (Fasta) | MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG STDPPQSPQG 60 ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA VITKKVADLV GFLLLKYRAR 120 EPVTKAEMLE SVIKNYKHCF PEIFGKASES LQLVFGIDVK EADPTGHSYV LVTCLGLSYD 180 GLLGDNQIMP KTGFLIIVLV MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT 240 QDLVQEKYLE YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA 300 ALREEEEGV |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D008545 ; Melanoma |
| DisGeNet (Curated) (count: 1) | C0025202; melanoma |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 8) (view all) | 124 YRAREPVTKAEMLES dbPAF
251 VQEKYLEYRQVPDSD dbPAF 276 RALAETSYVKVLEYV dbPAF 57 GSTDPPQSPQGASAF dbPAF 77 FTRQRQPSEGSSSRE dbPAF 80 QRQPSEGSSSREEEG dbPAF |
| Ubiquitination (count: 7) (view all) | 105 FRAVITKKVADLVGF PLMD
116 LVGFLLLKYRAREPV PLMD 125 RAREPVTKAEMLESV PLMD 134 EMLESVIKNYKHCFP PLMD 237 SAYGEPRKLLTQDLV PLMD 247 TQDLVQEKYLEYRQV PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||
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