P43354

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession NR4A2_HUMAN; P43354;
Entrez ID 4929
GenBank Protein ID NM_006186.3; XM_005246622.3; XM_017004219.1;
GenBank Nucleotide ID NP_006177.1; XP_005246679.1; XP_016859708.1;
Protein Name Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor)
Gene Name NR4A2; NOT; NURR1; TINUR
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
Sequence
(Fasta)		MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF 60
STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV 120
YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ 180
SPPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA 240
SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 300
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQEPSPPSP 360
PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW 420
AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG 480
EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT 540
FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF 599

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationParkinson's diseaseNS12517890097
[Reference]: These results indicate that Ser125 is critical for basal and ERK1/2-induced NURR1 activity and suggest a role for this and other NURR1 mutations in the regulation of dopamine synthesis and predisposition to Parkinson's disease.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 6)		MESH:D020261 ; Arsenic Poisoning
MESH:D001171 ; Arthritis, Juvenile
MESH:D015535 ; Arthritis, Psoriatic
MESH:D015179 ; Colorectal Neoplasms
OMIM:168600 ; PARKINSON DISEASE, LATE-ONSET
MESH:D012871 ; Skin Diseases

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 21)
(view all)		 125       GSVYYKPSSPPTPTT     dbPAF
126       SVYYKPSSPPTPTTP     dbPAF
129       YKPSSPPTPTTPGFQ     dbPAF
132       SSPPTPTTPGFQVQH     dbPAF
177       VSRLSLFSFKQSPPG     dbPAF
181       SLFSFKQSPPGTPVS     dbPAF
Sumoylation
(count: 3)		 558       YLSKLLGKLPELRTL     PLMD
577       LQRIFYLKLEDLVPP     PLMD
91        SGQQSSIKVEDIQMH     PLMD