Tag | Content |
---|---|
UniProt Accession | CDN2A_HUMAN; P42771; |
Entrez ID | 1029 |
GenBank Protein ID | NM_000077.4; NM_001195132.1; NM_058197.4; XM_005251343.1; XM_011517679.1; |
GenBank Nucleotide ID | NP_000068.1; NP_001182061.1; NP_478104.2; XP_005251400.1; XP_011515981.1; |
Protein Name | Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A) |
Gene Name | CDKN2A; CDKN2; MTS1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
Sequence (Fasta) | MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA 60 ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE 120 LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD 157 |
|
Database | Annotation |
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Cancer Gene Census | melanoma, multiple other tumour types melanoma, pancreatic familial malignant melanoma |
CTD (Curated) (count: 51) (view all) | MESH:D000230
; Adenocarcinoma MESH:C562730 ; Adenocarcinoma Of Esophagus MESH:D000310 ; Adrenal Gland Neoplasms MESH:D018268 ; Adrenocortical Carcinoma MESH:D001932 ; Brain Neoplasms MESH:D020295 ; Brain Stem Neoplasms |
DisGeNet (Curated) (count: 72) (view all) | C0001418; Adenocarcinoma
C0001624; Adrenal Gland Neoplasms C0004114; Astrocytoma C0005695; Bladder Neoplasm C0006118; Brain Neoplasms C0007131; Non-Small Cell Lung Carcinoma |
HGMD (count: 160) (view all) | CD972118; Melanoma; Small deletions
CD951647; Melanoma; Small deletions CD024714; Melanoma; Small deletions CD972119; Melanoma; Small deletions CD951648; Melanoma; Small deletions CD961883; Melanoma; Small deletions |
GWASdb (count: 14) (view all) | rs3731245; Menopause (age at onset); obesity|type 2 diabetes mellitus|cardiovascular system disease|osteoporosis|breast cancer|Alzheimer's disease
rs3731239; Glaucoma; glaucoma rs3731239; Coronary artery calcification; coronary artery disease rs3731239; Glaucoma (primary open-angle); glaucoma rs36228836; Menopause (age at onset); obesity|type 2 diabetes mellitus|cardiovascular system disease|osteoporosis|breast cancer|Alzheimer's disease rs3731236; LDL cholesterol; atherosclerosis|coronary artery disease |
PTM | Modification Sites |
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Phosphorylation (count: 4) | 140 AAGGTRGSNHARIDA dbPAF
152 IDAAEGPSDIPD*** dbPAF 7 *MEPAAGSSMEPSAD dbPAF 8 MEPAAGSSMEPSADW dbPAF |