| Tag | Content |
|---|---|
| UniProt Accession | CASP2_HUMAN; P42575; |
| Entrez ID | 835 |
| GenBank Protein ID | NM_001224.4; NM_032982.3; NM_032983.3; |
| GenBank Nucleotide ID | NP_001215.1; NP_116764.2; NP_116765.2; |
| Protein Name | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] |
| Gene Name | CASP2; ICH1; NEDD2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. |
| Sequence (Fasta) | MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL 60 LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT 120 TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT 180 PEFYQTHFQL AYRLQSRPRG LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV 240 HVLCDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF 300 DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK EKLPKMRLPT 360 RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD MHVADMLVKV NALIKDREGY 420 APGTEFHRCK EMSEYCSTLC RHLYLFPGHP PT 453 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D002292
; Carcinoma, Renal Cell MESH:D008607 ; Intellectual Disability |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 10) (view all) | 139 LSCDYDLSLPFPVCE dbPAF
151 VCESCPLYKKLRLST dbPAF 157 LYKKLRLSTDTVEHS dbPAF 158 YKKLRLSTDTVEHSL dbPAF 340 DGKNHAGSPGCEESD dbPAF 368 RSDMICGYACLKGTA dbPAF |
| Ubiquitination (count: 14) (view all) | 15 SWSTFQHKELMAADR PLMD
168 VEHSLDNKDGPVCLQ PLMD 177 GPVCLQVKPCTPEFY PLMD 214 NVHFTGEKELEFRSG PLMD 254 TAQEMQEKLQNFAQL PLMD 311 NCPSLQNKPKMFFIQ PLMD |
| Sumoylation (count: 1) | 77 MRELIQAKVGSFSQN PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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