P42230

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession STA5A_MOUSE; P42230;
Entrez ID 20850
GenBank Protein ID NM_011488.3; XM_006532721.1; XM_006532722.1; XM_017314402.1;
GenBank Nucleotide ID NP_035618.1; XP_006532784.1; XP_006532785.1; XP_017169891.1;
Protein Name Signal transducer and activator of transcription 5A (Mammary gland factor)
Gene Name Stat5a; Mgf; Mpf
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionCarries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Sequence
(Fasta)		MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRGQATQL 60
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV 120
REANNCSSPA GVLVDAMSQK HLQINQRFEE LRLITQDTEN ELKKLQQTQE YFIIQYQESL 180
RIQAQFAQLG QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL 240
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 300
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 360
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS 420
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA 480
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNI 540
SSNHLEDYNS MSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK 600
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPDRNL WNLKPFTTRD FSIRSLADRL 660
GDLNYLIYVF PDRPKDEVFA KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS TDAGASATYM 720
DQAPSPVVCP QPHYNMYPPN PDPVLDQDGE FDLDESMDVA RHVEELLRRP MDSLDARLSP 780
PAGLFTSARS SLS 794

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationT cell lymphomaU9548458
[Reference]: We report here that both DNA binding activities and tyrosine phosphorylation of STAT3 and STAT5, but not STAT1, are constitutively enhanced in the mouse T cell lymphoma LSTRA, which is a well-characterized cell line that overexpresses Lck protein and exhibits high levels of Lck kinase activity.
2Serine PhosphorylationLeukemiaUS72524263804
[Reference]: In cultured bone marrow cells, expression of a STAT5 mutant lacking the S725 and S779 phosphorylation sites (STAT5(SASA)) prohibits transformation and induces apoptosis. Accordingly, STAT5(SASA) BCR-ABL(+) cells display a strongly reduced leukemic potential in vivo, predominantly caused by loss of S779 phosphorylation that prevents the nuclear translocation of STAT5.?
3Serine PhosphorylationLeukemiaUS77924263804
[Reference]: Accordingly, STAT5(SASA) BCR-ABL(+) cells display a strongly reduced leukemic potential in vivo, predominantly caused by loss of S779 phosphorylation that prevents the nuclear translocation of STAT5. Three distinct lines of evidence indicate that S779 is phosphorylated by group I p21-activated kinase (PAK).

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 11)
(view all)		MESH:D000230 ; Adenocarcinoma
MESH:D001943 ; Breast Neoplasms
MESH:D002277 ; Carcinoma
MESH:D044584 ; Carcinoma, Ductal
MESH:D002285 ; Carcinoma, Intraductal, Noninfiltrating
MESH:D018275 ; Carcinoma, Lobular

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 17)
(view all)		 114       RCIRHILYNEQRLVR     dbPAF
127       VREANNCSSPAGVLV     dbPAF
128       REANNCSSPAGVLVD     dbPAF
171       KLQQTQEYFIIQYQE     dbPAF
682       KDEVFAKYYTPVLAK     dbPAF
683       DEVFAKYYTPVLAKA     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource