| Tag | Content |
|---|---|
| UniProt Accession | STA5A_HUMAN; P42229; |
| Entrez ID | 6776 |
| GenBank Protein ID | NM_001288718.1; NM_001288719.1; NM_001288720.1; NM_003152.3; |
| GenBank Nucleotide ID | NP_001275647.1; NP_001275648.1; NP_001275649.1; NP_003143.2; |
| Protein Name | Signal transducer and activator of transcription 5A |
| Gene Name | STAT5A; STAT5 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. |
| Sequence (Fasta) | MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL 60 LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQKTYDR CPLELVRCIR HILYNEQRLV 120 REANNCSSPA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL 180 RIQAQFAQLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 240 RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 300 QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 360 NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS 420 LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA 480 TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN 540 SSSHLEDYSG LSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK 600 QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPERNL WNLKPFTTRD FSIRSLADRL 660 GDLSYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGGSSATY 720 MDQAPSPAVC PQAPYNMYPQ NPDHVLDQDG EFDLDETMDV ARHVEELLRR PMDSLDSRLS 780 PPAGLFTSAR GSLS 795 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 11) (view all) | MESH:D000230
; Adenocarcinoma MESH:D001943 ; Breast Neoplasms MESH:D002277 ; Carcinoma MESH:D044584 ; Carcinoma, Ductal MESH:D002285 ; Carcinoma, Intraductal, Noninfiltrating MESH:D018275 ; Carcinoma, Lobular |
| GWASdb (count: 1) | rs16967637; Aortic root size; cardiovascular system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 24) (view all) | 114 RCIRHILYNEQRLVR dbPAF
127 VREANNCSSPAGILV dbPAF 128 REANNCSSPAGILVD dbPAF 193 FAQLAQLSPQERLSR dbPAF 22 LRQMQVLYGQHFPIE dbPAF 245 QLLRKQQTIILDDEL dbPAF |
| Acetylation (count: 3) | 347 QVLKTQTKFAATVRL PLMD
696 KAVDGYVKPQIKQVV PLMD 84 GEDGFLLKIKLGHYA PLMD |
| Ubiquitination (count: 13) (view all) | 163 QDTENELKKLQQTQE PLMD
164 DTENELKKLQQTQEY PLMD 207 RETALQQKQVSLEAW PLMD 235 ELAEKHQKTLQLLRK PLMD 242 KTLQLLRKQQTIILD PLMD 384 QQAKSLLKNENTRNE PLMD |
| Sumoylation (count: 3) | 384 QQAKSLLKNENTRNE PLMD
696 KAVDGYVKPQIKQVV PLMD 700 GYVKPQIKQVVPEFV PLMD |