P42227

※ Protein Information

Tag	Content
UniProt Accession	STAT3_MOUSE; P42227;
Entrez ID	20848
GenBank Protein ID	NM_213659.3; NM_213660.3;
GenBank Nucleotide ID	NP_998824.1; NP_998825.1;
Protein Name	Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene Name	Stat3; Aprf
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of n(view all) Functional Description Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (PubMed:12594516). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:16825198). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (PubMed:20215569). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (PubMed:23401489).
Sequence (Fasta)	MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL 60 LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA 120 TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK 180 SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL 240 ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 300 HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY 360 QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN 420 GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY 480 NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS 540 GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 600 KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM 660 DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN 720 TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDMD LTSECATSPM 771 Fasta Sequence >P42227\|Stat3; Aprf\|Mus musculus (Mouse) MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Phosphorylation	T cell lymphoma	U		9548458
1	[Reference]: We report here that both DNA binding activities and tyrosine phosphorylation of STAT3 and STAT5, but not STAT1, are constitutively enhanced in the mouse T cell lymphoma LSTRA, which is a well-characterized cell line that overexpresses Lck protein and exhibits high levels of Lck kinase activity.
2	Tyrosine Phosphorylation	Squamous cell carcinoma	U	Y705	19934324
2	[Reference]: Increased Fyn activity decreases Notch1/NICD levels and promotes STAT3 phosphorylation

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 51) (view all)	MESH:D000230 ; Adenocarcinoma MESH:D001169 ; Arthritis, Experimental MESH:D001171 ; Arthritis, Juvenile MESH:D050197 ; Atherosclerosis MESH:D001284 ; Atrophy OMIM:615952 ; AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 MESH:D001327 ; Autoimmune Diseases MESH:D002545 ; Brain Ischemia MESH:D001943 ; Breast Neoplasms MESH:D002277 ; Carcinoma MESH:D002294 ; Carcinoma, Squamous Cell MESH:C535575 ; Carcinoma, squamous cell of head and neck MESH:D006332 ; Cardiomegaly MESH:D009202 ; Cardiomyopathies MESH:D002471 ; Cell Transformation, Neoplastic MESH:D003093 ; Colitis, Ulcerative MESH:D003110 ; Colonic Neoplasms MESH:C566858 ; Copper-Overload Cirrhosis MESH:D003922 ; Diabetes Mellitus, Type 1 MESH:D004195 ; Disease Models, Animal MESH:D005334 ; Fever MESH:D005355 ; Fibrosis MESH:D006521 ; Hepatitis, Chronic MESH:D065630 ; Hernias, Diaphragmatic, Congenital MESH:C567925 ; Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant MESH:D020244 ; Infarction, Middle Cerebral Artery MESH:D007249 ; Inflammation MESH:D007589 ; Job Syndrome MESH:D015459 ; Leukemia-Lymphoma, Adult T-Cell MESH:D015470 ; Leukemia, Myeloid, Acute MESH:D008113 ; Liver Neoplasms MESH:D008114 ; Liver Neoplasms, Experimental MESH:D008207 ; Lymphatic Metastasis MESH:D015458 ; Leukemia, T-Cell MESH:D017728 ; Lymphoma, Large-Cell, Anaplastic MESH:D016399 ; Lymphoma, T-Cell MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008325 ; Mammary Neoplasms, Experimental MESH:D008527 ; Medulloblastoma MESH:D008569 ; Memory Disorders MESH:D009362 ; Neoplasm Metastasis MESH:D002289 ; Carcinoma, Non-Small-Cell Lung MESH:D010051 ; Ovarian Neoplasms MESH:D010190 ; Pancreatic Neoplasms MESH:D011230 ; Precancerous Conditions MESH:D015452 ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma MESH:D011471 ; Prostatic Neoplasms MESH:D011565 ; Psoriasis MESH:D015427 ; Reperfusion Injury MESH:D013274 ; Stomach Neoplasms MESH:D002583 ; Uterine Cervical Neoplasms

Database

Annotation

CTD (Curated)
(count: 51)
(view all)

MESH:D000230 ; Adenocarcinoma
MESH:D001169 ; Arthritis, Experimental
MESH:D001171 ; Arthritis, Juvenile
MESH:D050197 ; Atherosclerosis
MESH:D001284 ; Atrophy
OMIM:615952 ; AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 10) (view all)	381 DVAALRGSRKFNILG dbPAF 45 IESQDWAYAASKESH dbPAF 539 LLGPGVNYSGCQITW dbPAF 701 HPEADPGSAAPYLKT dbPAF 705 DPGSAAPYLKTKFIC dbPAF 708 SAAPYLKTKFICVTP dbPAF 714 KTKFICVTPTTCSNT dbPAF 716 KFICVTPTTCSNTID dbPAF 721 TPTTCSNTIDLPMSP dbPAF 727 NTIDLPMSPRTLDSL dbPAF
Acetylation (count: 2)	370 KIKVCIDKDSGDVAA PLMD 631 VEKDISGKTQIQSVE PLMD
Ubiquitination (count: 10) (view all)	177 DDFDFNYKTLKSQGD PLMD 180 DFNYKTLKSQGDMQD PLMD 244 DEELADWKRRQQIAC PLMD 294 LQQKVSYKGDPIVQH PLMD 318 ELFRNLMKSAFVVER PLMD 363 PELNYQLKIKVCIDK PLMD 626 VTFTWVEKDISGKTQ PLMD 631 VEKDISGKTQIQSVE PLMD 707 GSAAPYLKTKFICVT PLMD 87 QHNLRRIKQFLQSRY PLMD
Malonylation (count: 1)	294 LQQKVSYKGDPIVQH PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

E9Q4N7	P42227	MINT
G3X8X0	P42227	MINT
H3BK65	P42227	MINT
O35387	P42227	IntAct
P04104	P42227	IntAct
P14602	P42227	IntAct
P16882	P42227	DIP
P42227	P70424	MINT
P42227	Q3TZW9	MINT
P42227	Q3UDL4	DIP
P42227	Q52L78	IntAct
P42227	Q60960	MINT
P42227	Q62120	DIP
P42227	Q7TMY8	IntAct
P42227	Q7TSH4	IntAct
P42227	Q80VH0	IntAct
P42227	Q8K1N2	IntAct
P42227	Q99KX1	IntAct
P42227	Q9CR59	MINT

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction