P42226

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession STAT6_HUMAN; P42226;
Entrez ID 6778
GenBank Protein ID NM_001178078.1; NM_001178079.1; NM_001178080.1; NM_003153.4; XM_006719575.2;
GenBank Nucleotide ID NP_001171549.1; NP_001171550.1; NP_001171551.1; NP_003144.3; XP_006719638.1;
Protein Name Signal transducer and activator of transcription 6 (IL-4 Stat)
Gene Name STAT6
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCarries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Sequence
(Fasta)
MSLWGLVSKM PPEKVQRLYV DFPQHLRHLL GDWLESQPWE FLVGSDAFCC NLASALLSDT 60
VQHLQASVGE QGEGSTILQH ISTLESIYQR DPLKLVATFR QILQGEKKAV MEQFRHLPMP 120
FHWKQEELKF KTGLRRLQHR VGEIHLLREA LQKGAEAGQV SLHSLIETPA NGTGPSEALA 180
MLLQETTGEL EAAKALVLKR IQIWKRQQQL AGNGAPFEES LAPLQERCES LVDIYSQLQQ 240
EVGAAGGELE PKTRASLTGR LDEVLRTLVT SCFLVEKQPP QVLKTQTKFQ AGVRFLLGLR 300
FLGAPAKPPL VRADMVTEKQ ARELSVPQGP GAGAESTGEI INNTVPLENS IPGNCCSALF 360
KNLLLKKIKR CERKGTESVT EEKCAVLFSA SFTLGPGKLP IQLQALSLPL VVIVHGNQDN 420
NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTNRGLL PEHFLFLAQK 480
IFNDNSLSME AFQHRSVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG 540
FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSPQIENIQ PFSAKDLSIR 600
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVPATIKMTV ERDQPLPTPE 660
LQMPTMVPSY DLGMAPDSSM SMQLGPDMVP QVYPPHSHSI PPYQGLSPEE SVNVLSAFQE 720
PHLQMPPSLG QMSLPFDQPH PQGLLPCQPQ EHAVSSPDPL LCSDVTMVED SCLSQPVTAF 780
PQGTWIGEDI FPPLLPPTEQ DLTKLLLEGQ GESGGGSLGA QPLLQPSHYG QSGISMSHMD 840
LRANPSW 848

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationDuctal carcinoma in situtumor tissueUY64123562473
[Reference]: We found that IRS1 and pSTAT6 were both highly expressed in ductal carcinoma in situ (DCIS)

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
solitary fibrous tumour, meningeal haemangiopericytoma
CTD (Curated)
(count: 4)
MESH:D003876 ; Dermatitis, Atopic
MESH:D004487 ; Edema
MESH:D006258 ; Head and Neck Neoplasms
MESH:D054364 ; Solitary Fibrous Tumors
HGMD
(count: 3)
CE041969; Atopic asthma, association with; Repeat variations
CE041970; Atopic asthma, protection, association with; Repeat variations
CR082031; Schistosomiasis infection, association with; Regulatory
GWASdb
(count: 9)
(view all)
rs1059513; IgE levels; selective IgE deficiency disease
rs1059513; Allergic sensitization; hypersensitivity reaction disease
rs1059513; Sensory disturbances after bilateral sagittal split ramus osteotomy; corneal anesthesia and hypoesthesia|sensory system disease
rs703817; Brain structure; Alzheimer's disease
rs841718; Brain structure; Alzheimer's disease
rs3024971; IgE levels; selective IgE deficiency disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 9)
(view all)
2         ******MSLWGLVSK     dbPAF
407       PIQLQALSLPLVVIV     dbPAF
525       FDGVLDLTKRCLRSY     dbPAF
641       MGKDGRGYVPATIKM     dbPAF
645       GRGYVPATIKMTVER     dbPAF
707       IPPYQGLSPEESVNV     dbPAF
Acetylation
(count: 3)
288       QVLKTQTKFQAGVRF     PLMD
319       RADMVTEKQARELSV     PLMD
647       GYVPATIKMTVERDQ     PLMD
Ubiquitination
(count: 14)
(view all)
252       AGGELEPKTRASLTG     PLMD
277       TSCFLVEKQPPQVLK     PLMD
288       QVLKTQTKFQAGVRF     PLMD
307       RFLGAPAKPPLVRAD     PLMD
319       RADMVTEKQARELSV     PLMD
366       LFKNLLLKKIKRCER     PLMD
Malonylation
(count: 1)
288       QVLKTQTKFQAGVRF     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource