Tag | Content |
---|---|
UniProt Accession | CAV1_RAT; P41350; |
Entrez ID | 25404 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Caveolin-1 |
Gene Name | Cav1; Cav |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. |
Sequence (Fasta) | MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID LVNRDPKHLN 60 DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSTIFGIP MALIWGIYFA 120 ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RISTQEEI 179 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 17) (view all) | MESH:D001281
; Atrial Fibrillation MESH:D001943 ; Breast Neoplasms MESH:D006332 ; Cardiomegaly MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D065627 ; Familial Primary Pulmonary Hypertension MESH:D005902 ; Glaucoma, Open-Angle |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 3) | 14 VDSEGHLYTVPIREQ dbPAF
2 ******MSGGKYVDS dbPAF 9 SGGKYVDSEGHLYTV dbPAF |
Acetylation (count: 5) | 26 REQGNIYKPNNKAMA PLMD
30 NIYKPNNKAMADEVN PLMD 39 MADEVNEKQVYDAHT PLMD 47 QVYDAHTKEIDLVNR PLMD 5 ***MSGGKYVDSEGH PLMD |
Ubiquitination (count: 5) | 26 REQGNIYKPNNKAMA PLMD
30 NIYKPNNKAMADEVN PLMD 39 MADEVNEKQVYDAHT PLMD 5 ***MSGGKYVDSEGH PLMD 65 HLNDDVVKIDFEDVI PLMD |