P41350

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession CAV1_RAT; P41350;
Entrez ID 25404
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Caveolin-1
Gene Name Cav1; Cav
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionInvolved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae.
Sequence
(Fasta)
MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVNEKQ VYDAHTKEID LVNRDPKHLN 60
DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSTIFGIP MALIWGIYFA 120
ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RISTQEEI 179

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationFibrotic renal diseasePY1423269647
[Reference]: Src-mediated?phosphorylation?of caveolin-1 on Y14 has also been implicated in signaling responses.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 17)
(view all)
MESH:D001281 ; Atrial Fibrillation
MESH:D001943 ; Breast Neoplasms
MESH:D006332 ; Cardiomegaly
MESH:D003921 ; Diabetes Mellitus, Experimental
MESH:D065627 ; Familial Primary Pulmonary Hypertension
MESH:D005902 ; Glaucoma, Open-Angle

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 3)
14        VDSEGHLYTVPIREQ     dbPAF
2         ******MSGGKYVDS     dbPAF
9         SGGKYVDSEGHLYTV     dbPAF
Acetylation
(count: 5)
26        REQGNIYKPNNKAMA     PLMD
30        NIYKPNNKAMADEVN     PLMD
39        MADEVNEKQVYDAHT     PLMD
47        QVYDAHTKEIDLVNR     PLMD
5         ***MSGGKYVDSEGH     PLMD
Ubiquitination
(count: 5)
26        REQGNIYKPNNKAMA     PLMD
30        NIYKPNNKAMADEVN     PLMD
39        MADEVNEKQVYDAHT     PLMD
5         ***MSGGKYVDSEGH     PLMD
65        HLNDDVVKIDFEDVI     PLMD